Abnormal Myocardial Contraction In Alpha(1A)- And Alpha(1B)-Adrenoceptor Double-Knockout Mice

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Abnormal Myocardial Contraction In Alpha(1A)- And Alpha(1B)-Adrenoceptor Double-Knockout Mice

Mccloskey Dt; Turnbull Lynne; Swigart P; O'Connell T; Simpson Pc; Baker Anthony
URI: http://hdl.handle.net/10453/9626
Date: 2003

Abstract:

We used double-knockout mice (ABKO) lacking both predominant myocardial alpha(1)-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) to determine if alpha(1)-ARs are required for normal myocardial contraction. Langendorff-perfused ABKO hearts had

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