False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology

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dc.contributor.author Karim, Rooshdiya en_US
dc.contributor.author Scolyer, Richard en_US
dc.contributor.author Li, Wei en_US
dc.contributor.author Mckinnon, J en_US
dc.contributor.author Li, Ling-Xi en_US
dc.contributor.author Uren, Roger en_US
dc.contributor.author Lam, Stella en_US
dc.contributor.author Beavis, Alison en_US
dc.contributor.author Dawson, Michael en_US
dc.contributor.author Doble, Philip en_US
dc.contributor.author Hoon, Dave en_US
dc.contributor.author Thompson, John en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:50:43Z
dc.date.available 2010-05-28T09:50:43Z
dc.date.issued 2008 en_US
dc.identifier 2008004242 en_US
dc.identifier.citation Karim Rooshdiya et al. 2008, 'False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology', Lippincott Williams & Wilkins, vol. 247, no. 6, pp. 1003-1010. en_US
dc.identifier.issn 0003-4932 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/9605
dc.description.abstract OBJECTIVE: To investigate a cohort of melanoma patients with false negative (FN) sentinel node (SN) biopsies (SNBs) to identify the reasons for the FN result. SUMMARY OF BACKGROUND DATA: SNB is a highly efficient staging method in melanoma patients. However, with long-term follow-up FN SNB results of up to 25% have been reported. METHODS: Seventy-four SNs from 33 patients found to have had an FN SNB were analyzed by reviewing the lymphoscintigraphy, surgical data, and histopathology, and by assessing nodal tissue using multimarker real-time quantitative reverse transcription (qRT) polymerase chain reaction, and antimony concentration measurements (as a marker of "true" SN status) using inductively coupled plasma mass spectroscopy. RESULTS: Nine SNs (12%) from 9 patients (27%) had evidence of melanoma on histopathologic review. Twelve SNs (16%) from 10 patients (30%) were qRT(+). Four of these 12 SNs were positive on histopathology review and 8 were negative. Four patients (12%) were upstaged by qRT. Sixteen patients had their SNB histology, lymphoscintigraphy, and surgical data reviewed. Identifiable causes of the FN SNBs were not found after review of all modalities in 4 patients. SNs from all 4 patients had antimony levels indicative of an SN. Of the SNs evaluable by qRT, 1 was qRT(+) and 7 SNs from 2 patients were qRT(-). CONCLUSIONS: An FN SN can occur because of deficiencies in nuclear medicine, surgery, or pathology. qRT can detect "occult" metastatic melanoma in SNs that have been identified as negative by histopathology. A? 2008 Lippincott Williams & Wilkins, Inc. en_US
dc.language en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.relation.isbasedon http://dx.doi.org/10.1097/SLA.0b013e3181724f5e en_US
dc.title False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology en_US
dc.parent Annals of Surgery en_US
dc.journal.volume 247 en_US
dc.journal.number 6 en_US
dc.publocation United States en_US
dc.identifier.startpage 1003 en_US
dc.identifier.endpage 1010 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 110300 en_US
dc.personcode 0000049775 en_US
dc.personcode 0000020026 en_US
dc.personcode 0000059629 en_US
dc.personcode 0000022944 en_US
dc.personcode 0000020024 en_US
dc.personcode 0000020027 en_US
dc.personcode 0000049776 en_US
dc.personcode 990445 en_US
dc.personcode 910324 en_US
dc.personcode 010494 en_US
dc.personcode 0000049777 en_US
dc.personcode X000017029 en_US
dc.percentage 100 en_US
dc.classification.name Clinical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords en_US

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