Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues

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dc.contributor.author Kerr, Ian en_US
dc.contributor.author Jones, Peter en_US
dc.contributor.author George, Anthony en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:49:29Z
dc.date.available 2010-05-28T09:49:29Z
dc.date.issued 2009 en_US
dc.identifier 2009000933 en_US
dc.identifier.citation Kerr Ian, Jones Peter, and George Anthony 2009, 'Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues', Blackwell Publishing, vol. 277, pp. 550-563. en_US
dc.identifier.issn 1742-464X en_US
dc.identifier.other C5 en_US
dc.identifier.uri http://hdl.handle.net/10453/9419
dc.description.abstract One of the Holy Grails of ATP-binding cassette transporter research is a structural understanding of drug binding and transport in a eukaryotic multidrug resistance pump. These transporters are front-line mediators of drug resistance in cancers and represent an important therapeutic target in future chemotherapy. Although there has been intensive biochemical research into the human multidrug pumps, their 3D structure at atomic resolution remains unknown. The recent determination of the structure of a mouse P-glycoprotein at subatomic resolution is complemented by structures for a number of prokaryotic homologues. These structures have provided advances into our knowledge of the ATP-binding cassette exporter structure and mechanism, and have provided the template data for a number of homology modelling studies designed to reconcile biochemical data on these clinically important proteins. en_US
dc.language en_US
dc.publisher Blackwell Publishing en_US
dc.relation.isbasedon http://dx.doi.org/10.1111/j.1742-4658.2009.07486.x en_US
dc.title Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues en_US
dc.parent FEBS Journal en_US
dc.journal.volume 277 en_US
dc.journal.number en_US
dc.publocation United Kingdom en_US
dc.identifier.startpage 550 en_US
dc.identifier.endpage 563 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 110100 en_US
dc.personcode 0000049530 en_US
dc.personcode 020174 en_US
dc.personcode 860231 en_US
dc.percentage 100 en_US
dc.classification.name Medical Biochemistry and Metabolomics en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords ABC transporter,ABCC1,ABCG2, homology modelling,MsbA,multidrug pump,P-glycoprotein ,Sav1866,structure,transport mechanism en_US
dc.staffid 860231 en_US


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