Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging

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dc.contributor.author Jones, Anthony en_US
dc.contributor.author Milthorpe, Bruce en_US
dc.contributor.author Averdunk, Holger en_US
dc.contributor.author Limaye, Ajay en_US
dc.contributor.author Senden, Tim en_US
dc.contributor.author Sakellariou, Arthur en_US
dc.contributor.author Sheppard, Adrian en_US
dc.contributor.author Sok, Rob en_US
dc.contributor.author Knackstedt, Mark en_US
dc.contributor.author Brandwood, Arthur en_US
dc.contributor.author Hutmacher, Dietmar en_US
dc.contributor.author Rohner, Dennis en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:48:27Z
dc.date.available 2010-05-28T09:48:27Z
dc.date.issued 2004 en_US
dc.identifier 2008004380 en_US
dc.identifier.citation Jones Anthony et al. 2004, 'Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging', Elsevier Inc, vol. 25, no. 20, pp. 4947-4954. en_US
dc.identifier.issn 0142-9612 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/9258
dc.description.abstract This paper illustrates the utility of micro-computed tomography (micro-CT) to study the process of tissue engineered bone growth. A micro-CT facility for imaging and visualising biomaterials in three dimensions (3D) is described. The facility is capable of acquiring 3D images made up of 20003 voxels on specimens up to 60 mm in extent with resolutions down to 2 ?m. This allows the 3D structure of tissue engineered materials to be imaged across three orders of magnitude of detail. The capabilities of micro-CT are demonstrated by imaging the Haversian network within human femoral cortical bone (distal diaphysis) and bone ingrowth into a porous scaffold at varying resolutions. Phase identification combined with 3D visualisation enables one to observe the complex topology of the canalicular system of the cortical bone. Imaging of the tissue engineered bone at a scale of 1 cm and resolutions of 10 ?m allows visualisation of the complex ingrowth of bone into the polymer scaffold. Further imaging at 2 ?m resolution allows observation of bone ultra-structure. These observations illustrate the benefits of tomography over traditional techniques for the characterisation of bone morphology and interconnectivity and performs a complimentary role to current histomorphometric techniques. en_US
dc.language en_US
dc.publisher Elsevier Inc en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.biomaterials.2004.01.047 en_US
dc.title Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging en_US
dc.parent Biomaterials en_US
dc.journal.volume 25 en_US
dc.journal.number 20 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 4947 en_US
dc.identifier.endpage 4954 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 090300 en_US
dc.personcode 0000048895 en_US
dc.personcode 105631 en_US
dc.personcode 0000048934 en_US
dc.personcode 0000048935 en_US
dc.personcode 0000048937 en_US
dc.personcode 0000048936 en_US
dc.personcode 0000048897 en_US
dc.personcode 0000048938 en_US
dc.personcode 0000048899 en_US
dc.personcode 0000048939 en_US
dc.personcode 0000048898 en_US
dc.personcode 0000049929 en_US
dc.percentage 100 en_US
dc.classification.name Biomedical Engineering en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Image analysis; Scaffold; Bone tissue engineering; Micro-structure; X-ray micro-computed tomography en_US


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