Treated xenografts as gliding tendon prostheses in an ovine model

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Show simple item record Milthorpe, Bruce en_US Schindhelm, K en_US Howlett, C en_US Hall, P en_US Roger, G en_US
dc.contributor.editor en_US 2010-05-28T09:48:20Z 2010-05-28T09:48:20Z 1991 en_US
dc.identifier 2008004355 en_US
dc.identifier.citation Milthorpe Bruce et al. 1991, 'Treated xenografts as gliding tendon prostheses in an ovine model', Elsevier Inc, vol. 12, no. 6, pp. 577-583. en_US
dc.identifier.issn 0142-9612 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract A model for testing the properties of gliding tendon grafts has been developed that allows anastomoses to be evaluated separately from the mid-portion of the graft. In addition, two different graft materials may be implanted in one sheep foreleg whilst maintaining control (not operated) tendons in both the operated leg and contralateral foreleg. The model has been used to evaluate the response of xenografts made from chemically treated kangaroo tail tendon (KTT) compared with autografts. At 3 month the mid-sections of the glutaraldehyde-fixed xenografts maintained between 57 and 82% of their initial ultimate tensile strength whereas lyophilized KTT dropped to 10% and autografts retained 91% of initial strength. Sterilization by gamma-radiation of wet xenografts did not affect the material and implant properties significantly. Longer term studies are necessary to determine the resorption behaviour of the xenografts. Anastomosis strengths were found to be about the same for all grafts, at about 25% of the strength of the original tendon. Alternatives need to be investigated to improve this strength. en_US
dc.language en_US
dc.publisher Elsevier Inc en_US
dc.title Treated xenografts as gliding tendon prostheses in an ovine model en_US
dc.parent Biomaterials en_US
dc.journal.volume 12 en_US
dc.journal.number 6 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 577 en_US
dc.identifier.endpage 583 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 090300 en_US
dc.personcode 105631 en_US
dc.personcode 0000049739 en_US
dc.personcode 0000049868 en_US
dc.personcode 0000049869 en_US
dc.personcode 0000049738 en_US
dc.percentage 100 en_US Biomedical Engineering en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords Tendons; xenografts; autografts; mechanical properties; glutaraldehyde en_US

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