Optical endpoint sensing in an automatic whole blood clotting timer

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dc.contributor.author Bertram, Christopher en_US
dc.contributor.author Milthorpe, Bruce en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:47:58Z
dc.date.available 2010-05-28T09:47:58Z
dc.date.issued 1984 en_US
dc.identifier 2008004098 en_US
dc.identifier.citation Bertram Christopher and Milthorpe Bruce 1984, 'Optical endpoint sensing in an automatic whole blood clotting timer', Springer, vol. 22, pp. 401-405. en_US
dc.identifier.issn 0140-0118 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/9177
dc.description.abstract Most clotting time estimations are performed manually, although attempts have been made previously to automate them. The two major methods for automatically detecting the formation of the gel-like clot are mechanical (viscometric) and optical. The latter is superior in terms of accuracy of timing and freedom from artefacts but can only be performed on blood plasma. This paper describes a device which combines centrifuging to remove red cells and optical sensing of clot formation into a single operation, therepy giving activated clotting times on a par with those obtained mechanically from whole blood. The system offers the advantage over mechanical sensing that no nondisposable parts come in contact with the blood thereby eliminating e major source of timing errors. The timer works with any liquid coagulation activator, and will also time plasma clotting. The two-chambered design of the cuvette allows the activator to be kept separate from the blood until rotor startup The start of centifugal action mixes the blood and activator and starts the time. Timing is stopped auto matically when the rate of increase of optical density in the plasma, owing to fibrin formation, reaches a predetermined fevel. en_US
dc.language en_US
dc.publisher Springer en_US
dc.relation.isbasedon http://dx.doi.org/10.1007/BF02447698 en_US
dc.title Optical endpoint sensing in an automatic whole blood clotting timer en_US
dc.parent Medical & Biological Engineering & Computing en_US
dc.journal.volume 22 en_US
dc.journal.number en_US
dc.publocation Germany en_US
dc.identifier.startpage 401 en_US
dc.identifier.endpage 405 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 090303 en_US
dc.personcode 0000023765 en_US
dc.personcode 105631 en_US
dc.percentage 100 en_US
dc.classification.name Biomedical Instrumentation en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Centrifugal analysis - Medical instrumentation - Plasma elotting - Whole blood clotting Patents pending en_US
dc.staffid 105631 en_US

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