Fasciola Hepatica Cathepsin L-like Proteases: Biology, Function, And Potential In The Development Of First Generation Liver Fluke Vaccines

Abstract

Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite through the tissues of its host, and also participate in functions such as feeding and immune evasion. The major proteases, cathepsin L1 (FheCL1) and catheps