The effect of the microtubule inhibitor tubulozole-C on the tegument of triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica

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dc.contributor.author Robinson, Mark en_US
dc.contributor.author Trudgett, A en_US
dc.contributor.author Hoey, Elizabeth en_US
dc.contributor.author Fairweather, I en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:46:11Z
dc.date.available 2010-05-28T09:46:11Z
dc.date.issued 2003 en_US
dc.identifier 2009005086 en_US
dc.identifier.citation Robinson Mark et al. 2003, 'The effect of the microtubule inhibitor tubulozole-C on the tegument of triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica', Springer, vol. 91, no. 2, pp. 117-129. en_US
dc.identifier.issn 0932-0113 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8902
dc.description.abstract The benzimidazole derivative, triclabendazole is the main drug used against Fasciola hepatica, although its precise mode of action remains to be fully determined. Previous studies have suggested that triclabendazole acts as a microtubule inhibitor in the same manner as tubulozole-C. Consequently, flukes from triclabendazole-susceptible and triclabendazole-resistant isolates were treated with tubulozole-C (1?10?6 M) in vitro and changes in tegumental morphology and tubulin distribution within the tegument were monitored by scanning and transmission electron microscopy, together with tubulin immunocytochemistry. Tubulozole-C caused severe disruption within the tegument of triclabendazole-susceptible flukes. Tubulin immunoreactivity diminished within the tegumental syncytium of the triclabendazole-susceptible flukes following treatment with tubulozole-C. In contrast, tubulozole-C caused only minor disruption of the tegument in triclabendazole-resistant F. hepatica and did not significantly alter the pattern of tubulin immunostaining within the tegumental syncytium. The results of the present study indicate that tubulozole-C and triclabendazole share the same target molecule and that triclabendazole-resistant flukes are also cross-resistant to tubulozole-C. en_US
dc.language en_US
dc.publisher Springer en_US
dc.relation.isbasedon http://dx.doi.org/10.1007/s00436-003-0953-z en_US
dc.title The effect of the microtubule inhibitor tubulozole-C on the tegument of triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica en_US
dc.parent Parasitology Research en_US
dc.journal.volume 91 en_US
dc.journal.number 2 en_US
dc.publocation Berlin, Germany en_US
dc.identifier.startpage 117 en_US
dc.identifier.endpage 129 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 070700 en_US
dc.personcode 100777 en_US
dc.personcode 0000033423 en_US
dc.personcode 0000049705 en_US
dc.personcode 0000033422 en_US
dc.percentage 50 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US


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