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Now showing items 21-40 of 1916

Continuous, non-invasive volume-clamp blood pressure: determinants of performance

Lal Saroj; Mihailidou A.; Cejnar M.; Henderson Robyn; Jones M.; Hunyor S. (Current Science, 1993)

Objective: To test a prototype hydraulic, non-invasive, continuous finger blood pressure monitor based on the volume-clamp principle for procedure-related factors likely to influence precision. Design: The influence of ...
Monoclonal-Antibody 2B6-F2 Identifies A Subset Of Murine Natural-Killer-Cells With Receptors For YAC-1 And WEHI-164 Targets

Martiniello-Wilks Rosetta; Smart Yc; Burton Rc (Academic Press Inc Jnl-Comp Subscriptions, 1994)

This study reports the generation of rat MoAb 2B6-F2 (IgG2a) that identifies a subpopulation of murine NK cells in the spleen, bone marrow, peripheral blood, lung, and peritoneal leukocytes. By flow cytometry, 2B6-F2 reacted ...
Human Colon-Cancer Cell-Lines Show A Diverse Pattern Of Nitric-Oxide Synthase Gene-Expression And Nitric-Oxide Generation

Jenkins David; Charles Ian; Baylis Sa; Lelchuk R; Radomski Mw; Moncada S (Stockton Press, 1994)

A panel of human colonic adenocarcinoma cell lines was examined both for expression of mRNAs of the nitric oxide synthase (NOS) gene family and for evidence of enzymic activity based on citrulline and nitrite (NO2-) ...
Expression Of The Bordetella-Pertussis P.69 Pertactin Adhesin In Escherichia-Coli - Fate Of The Carboxy-Terminal Domain

Charles Ian; Fairweather N; Pickard D; Beesley J; Anderson Rob; Dougan G; Roberts Ms (Soc General Microbiology, 1994)

The mature pertactin protein (P.69) of Bordetella pertussis can be isolated from the bacterial cell surface as a polypeptide with an apparent molecular mass of 69 000 Da as determined by sodium dodecyl sulphate gel ...
Xenografts for tendon and ligament repair

Milthorpe Bruce (Elsevier Inc, 1994)
Escherichia-coli Contains A Set Of Genes Homologous To Those Involved In Protein Secretion, DNA Uptake And The Assembly Of Type-4 Fimbriae In Other Bacteria

Whitchurch Cynthia; Mattick John (Elsevier Science Bv, 1994)

A specialised system involved in a diverse array of functions, including the biogenesis of fimbriae, protein secretion and DNA uptake, has recently been found to be widespread in the eubacteria. These systems have in common ...
An Experimental Model of Affinity Cell Separation

Nordon Robert; Milthorpe Bruce; Schindhelm K; Slowiaczek Peter (Wiley-Liss Inc, 1994)

Cell affinity separations are based on the selective attachment of cell pheno-type using antibody or lectins specific for cell surface markers. The major physico-chemical factors which influence ligand-mediated cell adhesion ...
Measurement of Microtomy Induced Section Distortion and Its Correction for 3-Dimensional Histological Reconstructions

Jones Allan; Milthorpe Bruce; Howlett C (Wiley-Liss Inc, 1994)

The presence of microtomy induced distortion in paraffin sections is a significant hindrance to the accurate alignment of sections for three-dimensional reconstructive techniques. Measurement of section distortion in various ...
Physiological influences on continuous finger and simultaneous intra-arterial blood pressure

Lal Saroj; Henderson Robyn; Cejnar Michael; Hart Michael; Hunyor Stephen (American Heart Association, 1995)

Because of the clinical and experimental utility of continuous finger blood pressure measurements and the need for accuracy, we tested the perfonnance of a new hydraulic device in 22 consecutive hypertensive subjects during ...
Enzymatic Characterization Of Recombinant Murine Inducible Nitric-Oxide Synthase

Moss D; Wei Xiao; Liew Fy; Moncada S; Charles Ian (Elsevier Science Bv, 1995)

A complementary DNA (cDNA) encoding murine inducible nitric oxide synthase was cloned from activated J774 macrophages. Expression of this cDNA in a baculovirus-insect cell system allowed comparison of the recombinant enzyme ...
Altered Immune-Responses In Mice Lacking Inducible Nitric-Oxide Synthase

Wei Xiao; Charles Ian; Smith Andrew; Ure J; Feng Chongyi; Huang Freeman; Xu D.; Muller Warren; Moncada S; Liew Fy (Macmillan Magazines Ltd, 1995)

NITRIC oxide (NO) is important in many biological functions(1-5). It is generated from L-arginine by the enzyme NO synthase (NOS), The cytokine-inducible NOS (iNOS) is activated by several immunological stimuli, leading ...
Studies on the localization and expression of nitric oxide synthase using histochemical techniques

Norris P; Charles Ian; Scorer C.; Emson Piers (Springer Netherlands, 1995)

This review provides an update on the variety of histochemical techniques available for the cellular localization and expression of nitric oxide synthase in formalin-fixed tissue sections. The techniques of immunohistochemistry ...
Shielding of augmented tendon-tendon repair

Rogers G; Milthorpe Bruce; Schindhelm K; Howlett C; Roe S (Elsevier Inc, 1995)
The effects of sintering atmosphere on the chemical compatibility of hydroxyapatite and particulate additives at 1200 C

Ruys A; Brandwood Arthur; Milthorpe Bruce; Dickson M; Zeigler K; Sorrell Charles (Springer New York LLC, 1995)
Sintering effects on the strength hydroxyapatite

Ruys A; Wei M; Sorrell Charles; Dickson M; Brandwood Arthur; Milthorpe Bruce (Elsevier Inc, 1995)
Beta cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model

O'Brien Bronwyn; Harmon Brian; Cameron Donald; Allan David (Wiley, 1996)

Although insulin-dependent diabetes mellitus (IDDM) results from irreversible loss of beta cells, the mode of cell death responsible for this loss has not previously been categorized. In this study, the multiple low-dose ...
Clinical Rationale For Topical Antimicrobial Preparations

Langford Jh; Benrimoj Charlie (W B Saunders Co Ltd, 1996)

Despite innovations and advancement in drug design, drug delivery and biotechnology, the selection of drug concentrations in topical preparations has remained largely unchanged for the past 40 years. It is doubtful that ...
Ly-6C(+) natural T (NT) cells mediate immune surveillance against NK-sensitive and NK-resistant transplantable tumours in certain strains of mice

Martiniello-Wilks Rosetta; Burton Rc; Smart Yc (Wiley-Liss, 1996)

We have previously shown that anti-Ly-6C monoclonal antibody (MAb) 2B6-F2 identifies a subset of (CBA +/- C57BL/6)F-1 splenic NK-1.1(+) natural T (NT) cells which kill the NK-sensitive YAC-I target in vitro. Furthermore, ...
A Comparison Of Two Quality-of-life Questionnaires For Cancer Clinical Trials: The Functional Living Index-cancer (flic) And The Quality Of Life Questionnaire Core Module (qlq-c30)

King Madeleine; Dobson Aj; Harnett Paul (Pergamon-elsevier Science Ltd, 1996)

Choosing a measuring instrument for a study raises the question of whether instruments designed for the same purpose produce the same results. We investigated this question for two instruments designed to measure subjective ...
Role Of The Bordetella Pertussis P.69/Pertactin Protein And The P.69/Pertactin Rgd Motif In The Adherence To And Invasion Of Mammalian Cells

Everest P; Li Jingli; Douce G; Charles Ian; Deazavedo J; Chatfield S; Dougan G; Roberts Ms (Soc General Microbiology, 1996)

The role of the Bordetella pertussis P.69/pertactin protein in mammalian cell adhesion and invasion was investigated. Salmonella strains expressing surface-associated P.69/pertactin from a chromosomally located pm gene ...

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