An open-loop model for investigating mammalian thermosensitivity

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dc.contributor.author Gordon, Christopher en_US
dc.contributor.author Haley, Cassandra en_US
dc.contributor.author Mclennan, Peter en_US
dc.contributor.author Tipton, Michael en_US
dc.contributor.author Mekjavia?, Igor en_US
dc.contributor.author Taylor, Nigel en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:45:21Z
dc.date.available 2010-05-28T09:45:21Z
dc.date.issued 2004 en_US
dc.identifier 2008007299 en_US
dc.identifier.citation Gordon Christopher et al. 2004, 'An open-loop model for investigating mammalian thermosensitivity', Elsevier, vol. 29, no. 7-8, pp. 703-707. en_US
dc.identifier.issn 0306-4565 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8768
dc.description.abstract We have developed, and herein describe, a simple, open-loop model in the rat, in which both skin and hypothalamic temperatures can be modified and clamped. A water-perfused thermode was positioned in the abdomen to drive hypothalamic temperature, and a water-perfused jacket was used to clamp skin temperature. These permitted the independent control of hypothalamic and skin temperatures. The former could be altered between 35 and 41 ?C whilst achieving an isothermal skin temperature clamp. Similarly, skin temperature could be modified between 22 and 42 ?C whilst hypothalamic temperature was clamped. Maximal hypothalamic heating and cooling rates were: 0.75 and -2.04 ?C h-1 100 g-1. We are currently using this animal model to investigate how central thermosensitivity is affected via manipulations of hypothalamic cooling rates. en_US
dc.language en_US
dc.publisher Elsevier en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.jtherbio.2004.08.043 en_US
dc.title An open-loop model for investigating mammalian thermosensitivity en_US
dc.parent Journal of Thermal Biology en_US
dc.journal.volume 29 en_US
dc.journal.number 7-8 en_US
dc.publocation Devon, UK en_US
dc.identifier.startpage 703 en_US
dc.identifier.endpage 707 en_US
dc.cauo.name FOH.Faculty of Health en_US
dc.conference Verified OK en_US
dc.for 060802 en_US
dc.personcode 044077 en_US
dc.personcode 0000052558 en_US
dc.personcode 0000052559 en_US
dc.personcode 0000052560 en_US
dc.personcode 0000052561 en_US
dc.personcode 0000052562 en_US
dc.percentage 100 en_US
dc.classification.name Animal Cell and Molecular Biology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Body temperature regulation; Core temperature; Model; Skin temperature; Threshold; Rats en_US


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