Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1

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dc.contributor.author Labbate, Maurizio en_US
dc.contributor.author Queck, Shu Yeong en_US
dc.contributor.author Koh, Kai Shyang en_US
dc.contributor.author Rice, Scott en_US
dc.contributor.author Givskov, Michael en_US
dc.contributor.author Kjelleberg, Staffan en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:45:14Z
dc.date.available 2010-05-28T09:45:14Z
dc.date.issued 2004 en_US
dc.identifier 2008003894 en_US
dc.identifier.citation Labbate Maurizio et al. 2004, 'Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1', Amer Soc Microbiology, vol. 186, pp. 692-698. en_US
dc.identifier.issn 0021-9193 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8749
dc.description.abstract Serratia liquefaciens MG1 contains an N-acylhomoserine lactone-mediated quorum-sensing system that is known to regulate swarming motility colonization. In this study, we describe for S. liquefaciens MG1 the development of a novel biofilm consisting of cell aggregates and differentiated cell types, such as cell chains and long filamentous cells. Furthermore, quorum sensing is shown to be crucial for normal biofilm development and for elaborate differentiation. A mutant of S. liquefaciens MG1 that was incapable of synthesizing extracellular signal formed a thin and nonmature biofilm lacking cell aggregates and differentiated cell chains. Signal-based complementation of this mutant resulted in a biofilm with the wild-type architecture. Two quorum-sensing-regulated genes (bsmA and bsmB) involved in biofilm development were identified, and we propose that these genes are engaged in fine-tuning the formation of cell aggregates at a specific point in biofilm development. en_US
dc.language en_US
dc.publisher Amer Soc Microbiology en_US
dc.relation.isbasedon http://dx.doi.org/10.1128/JB.186.3.692-698.2004 en_US
dc.title Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1 en_US
dc.parent Journal Of Bacteriology en_US
dc.journal.volume 186 en_US
dc.journal.number en_US
dc.publocation Washington DC, USA en_US
dc.identifier.startpage 692 en_US
dc.identifier.endpage 698 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060503 en_US
dc.personcode 106011 en_US
dc.personcode 0000050236 en_US
dc.personcode 0000050233 en_US
dc.personcode 0000050237 en_US
dc.personcode 0000050243 en_US
dc.personcode 0000027051 en_US
dc.percentage 100 en_US
dc.classification.name Microbial Genetics en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US


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