Biofilm formation and sloughing in Serratia marcescens is controlled by quorum sensing and nutrient conditions

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dc.contributor.author Rice, Scott en_US
dc.contributor.author Koh, Kai Shyang en_US
dc.contributor.author Queck, Shu Yeong en_US
dc.contributor.author Labbate, Maurizio en_US
dc.contributor.author Lam, Kin Wai en_US
dc.contributor.author Kjelleberg, Staffan en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:45:08Z
dc.date.available 2010-05-28T09:45:08Z
dc.date.issued 2005 en_US
dc.identifier 2008003896 en_US
dc.identifier.citation Rice Scott et al. 2005, 'Biofilm formation and sloughing in Serratia marcescens is controlled by quorum sensing and nutrient conditions', Amer Soc Microbiology, vol. 187, no. 10, pp. 3477-3485. en_US
dc.identifier.issn 0021-9193 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8733
dc.description.abstract We describe here a role for quorum sensing in the detachment, or sloughing, of Serratia marcescens filamentous biofilms, and we show that nutrient conditions affect the biofilm morphotype. Under reduced carbon or nitrogen conditions, S. marcescens formed a classical biofilm consisting of microcolonies. The filamentous biofilm could be converted to a microcolony-type biofilm by switching the medium after establishment of the biofilm. Similarly, when initially grown as a microcolony biofilm, S. marcescens could be converted back to a filamentous biofilm by increasing the nutrient composition. Under high-nutrient conditions, an N-acyl homoserine lactone quorum-sensing mutant formed biofilms that were indistinguishable from the wild-type biofilms. Similarly, other quorum-sensing-dependent behaviors, such as swarming motility, could be rendered quorum sensing independent by manipulating the growth medium. Quorum sensing was also found to be involved in the sloughing of the filamentous biofilm. The biofilm formed by the bacterium consistently sloughed from the substratum after approximately 75 to 80 h of development. en_US
dc.language en_US
dc.publisher Amer Soc Microbiology en_US
dc.relation.isbasedon http://dx.doi.org/10.1128/JB.187.10.3477-3485.2005 en_US
dc.title Biofilm formation and sloughing in Serratia marcescens is controlled by quorum sensing and nutrient conditions en_US
dc.parent Journal Of Bacteriology en_US
dc.journal.volume 187 en_US
dc.journal.number 10 en_US
dc.publocation Washington DC, USA en_US
dc.identifier.startpage 3477 en_US
dc.identifier.endpage 3485 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060503 en_US
dc.personcode 0000050237 en_US
dc.personcode 0000050233 en_US
dc.personcode 0000050236 en_US
dc.personcode 106011 en_US
dc.personcode 0000050234 en_US
dc.personcode 0000027051 en_US
dc.percentage 100 en_US
dc.classification.name Microbial Genetics en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US


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