Immunological interactions between 2common pathogens, the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica

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dc.contributor.author Miller, Catherine en_US
dc.contributor.author Smith, Nicholas en_US
dc.contributor.author Ikin, Rowan en_US
dc.contributor.author Boulter, Nicola en_US
dc.contributor.author Dalton, John en_US
dc.contributor.author Donnelly, Sheila en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:45:05Z
dc.date.available 2010-05-28T09:45:05Z
dc.date.issued 2009 en_US
dc.identifier 2008005731 en_US
dc.identifier.citation Miller Catherine et al. 2009, 'Immunological interactions between two common pathogens, the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica', Public Library of Science, vol. 4, no. 5, pp. 1-10. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/8727
dc.description.abstract The nature of the immune response to infection is dependent on the type of infecting organism. Intracellular organisms such as Toxoplasma gondii stimulate a Th1-driven response associated with production of IL-12, IFN-?, nitric oxide and IgG2a antibodies and classical activation of macrophages. In contrast, extracellular helminths such as Fasciola hepatica induce Th2 responses characterised by the production of IL-4, IL-5, IL-10 and IgG1 antibodies and alternative activation of macrophages. As co-infections with these types of parasites commonly exist in the field it is relevant to examine how the various facets of the immune responses induced by each may influence or counter-regulate that of the other. en_US
dc.language en_US
dc.publisher Public Library of Science en_US
dc.title Immunological interactions between 2common pathogens, the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica en_US
dc.parent PLoS ONE en_US
dc.journal.volume 4 en_US
dc.journal.number 5 en_US
dc.publocation USA en_US
dc.identifier.startpage 1 en_US
dc.identifier.endpage 10 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 070700 en_US
dc.personcode 970043 en_US
dc.personcode 960087 en_US
dc.personcode 103482 en_US
dc.personcode 011172 en_US
dc.personcode 030896 en_US
dc.personcode 995261 en_US
dc.percentage 100 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords en_US
dc.staffid 995261 en_US


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