Expression Of A Gi-Coupled Receptor In The Heart Causes Impaired Ca2+ Handling, Myofilament Injury, And Dilated Cardiomyopathy

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Expression Of A Gi-Coupled Receptor In The Heart Causes Impaired Ca2+ Handling, Myofilament Injury, And Dilated Cardiomyopathy

Mccloskey Dt; Turcato S; Wang Guan-Ying; Turnbull Lynne; Zhu Bo-Qing; Bambino T; Nguyen Ap; Lovett Dh; Nissenson Ra; Karliner Js; Baker Anthony
URI: http://hdl.handle.net/10453/8706
Date: 2008

Abstract:

Increased signaling by G(i)-coupled receptors has been implicated in dilated cardiomyopathy. To investigate the mechanisms, we used transgenic mice that develop dilated cardiomyopathy after conditional expression of a cardiac-targeted G(i)-coupled recept

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