Cleavage Of Hemoglobin By Hookworm Cathepsin D Aspartic Proteases And Its Potential Contribution To Host Specificity
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| dc.contributor.author | Williamson Alexandra | en_US |
| dc.contributor.author | Brindley Paul | en_US |
| dc.contributor.author | Abbenante Giovani | en_US |
| dc.contributor.author | Prociv P | en_US |
| dc.contributor.author | Berry C | en_US |
| dc.contributor.author | Girdwood K | en_US |
| dc.contributor.author | Pritchard Di | en_US |
| dc.contributor.author | Fairlie David | en_US |
| dc.contributor.author | Hotez Peter | en_US |
| dc.contributor.author | Dalton John | en_US |
| dc.contributor.author | Loukas Alexander | en_US |
| dc.contributor.editor | en_US | |
| dc.date.accessioned | 2010-05-28T09:44:52Z | |
| dc.date.available | 2010-05-28T09:44:52Z | |
| dc.date.issued | 2002 | en_US |
| dc.identifier | 2006012455 | en_US |
| dc.identifier.citation | Williamson Alexandra et al. 2002, 'Cleavage Of Hemoglobin By Hookworm Cathepsin D Aspartic Proteases And Its Potential Contribution To Host Specificity', Federation Amer Soc Exp Biol, vol. 16, no. 9, pp. 1458-0. | en_US |
| dc.identifier.issn | 0892-6638 | en_US |
| dc.identifier.other | C1 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10453/8693 | |
| dc.description.abstract | Human and canine hookworms are blood-feeding nematode parasites that reach the gut of nonpermissive mammalian hosts but fail to successfully feed, develop, and reproduce, presumably as a consequence of intimate coevolution between the parasite and its normal definitive (permissive) host. To identify molecular examples of host specificity in blood-feeding pathogens, we hypothesized that hookworm digestive proteases were more efficient at cleaving hemoglobin substrates from permissive than nonpermissive host species | en_US |
| dc.language | en_US | |
| dc.publisher | Federation Amer Soc Exp Biol | en_US |
| dc.relation.isbasedon | http://dx.doi.org/10.1096/fj.02-0181fje | en_US |
| dc.title | Cleavage Of Hemoglobin By Hookworm Cathepsin D Aspartic Proteases And Its Potential Contribution To Host Specificity | en_US |
| dc.parent | Faseb Journal | en_US |
| dc.journal.volume | 16 | en_US |
| dc.journal.number | 9 | en_US |
| dc.publocation | Bethesda, USA | en_US |
| dc.identifier.startpage | 1458 | en_US |
| dc.identifier.endpage | 0 | en_US |
| dc.cauo.name | SCI.Medical and Molecular Biosciences | en_US |
| dc.conference | Verified OK | en_US |
| dc.for | 060107 | en_US |
| dc.personcode | 0000033405;0000018481;0000021925;0000033410;0000046035;0000027195;0000033411;0000033412;0000033413;0000033414;030896 | en_US |
| dc.percentage | 000040 | en_US |
| dc.classification.name | Enzymes | en_US |
| dc.classification.type | FOR-08 | en_US |
| dc.edition | en_US | |
| dc.custom | en_US | |
| dc.date.activity | en_US | |
| dc.location.activity | en_US | |
| dc.description.keywords | Human Eosinophilic Enteritis; Adult Haemonchus-contortus; Blood-feeding Parasites; Ancylostoma-caninum; Plasmodium-falciparum; Caenorhabditis-elegans; In-vivo; Degradation; Infection; Identification | en_US |
| dc.staffid | George Washington University;Queensland Institute of Medical Research;Tulane University;University of Queensland | en_US |
