Alterations of the Birt-Hogg-Dube gene (BHD) in sporadic colorectal tumours

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Show simple item record Kahnoski, Katherine en_US Khoo, Sok en_US Nassif, Najah en_US Chen, Jin Dong en_US Lobo, Glenn en_US Segelov, Eva en_US Teh, Bin en_US
dc.contributor.editor en_US 2010-05-28T09:44:49Z 2010-05-28T09:44:49Z 2003 en_US
dc.identifier 2006008507 en_US
dc.identifier.citation Kahnoski Katherine et al. 2003, 'Alterations of the Birt-Hogg-Dube gene (BHD) in sporadic colorectal tumours', BMJ Publishing Group Ltd, vol. 40, no. 7, pp. 511-515. en_US
dc.identifier.issn 1468-6244 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract Colorectal cancer (CRC) is the third most common cancer diagnosed in both men and women, and the second most common cause of cancer deaths in the United States. There were approximately 150 000 new cases resulting in 57 000 deaths in 2002.1 CRC is one of the most studied cancer types and its underlying aetiology best, elucidated. Colorectal tumorigenesis involves a multistep process including genetic and epigenetic alterations of numerous CRC related genes that may act as either oncogenes or tumour suppressor genes.2-5 The majority of sporadic CRCs are characterised by deletions of large chromosomal segments, which are thought to represent the loss of wild type tumour suppressor genes.6 7 About 15% of sporadic CRCs, on the other hand, show microsatellite instability (MSI), characterised by the insertion and/or deletion of simple repeat sequences and indicative of the involvement of defective mismatch repair. en_US
dc.publisher BMJ Publishing Group Ltd en_US
dc.relation.hasversion Accepted manuscript version en_US
dc.title Alterations of the Birt-Hogg-Dube gene (BHD) in sporadic colorectal tumours en_US
dc.parent Journal of Medical Genetics en_US
dc.journal.volume 40 en_US
dc.journal.number 7 en_US
dc.publocation UK en_US
dc.identifier.startpage 511 en_US
dc.identifier.endpage 515 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060405 en_US
dc.personcode 0000031280 en_US
dc.personcode 0000031281 en_US
dc.personcode 030580 en_US
dc.personcode 0000031282 en_US
dc.personcode 10220527 en_US
dc.personcode 0000021973 en_US
dc.personcode 0000031285 en_US
dc.percentage 100 en_US Gene Expression (incl. Microarray and other genome-wide approaches) en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords en_US

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