A Novel Family Of Potentially Mobile DNA Elements Encoding Site-Specific Gene-Integration Functions - Integrons

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dc.contributor.author Hall, R en_US
dc.contributor.author Stokes, Hatch en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:44:32Z
dc.date.available 2010-05-28T09:44:32Z
dc.date.issued 1989 en_US
dc.identifier 2008005637 en_US
dc.identifier.citation Stokes Harold and Hall R 1989, 'A Novel Family Of Potentially Mobile DNA Elements Encoding Site-Specific Gene-Integration Functions - Integrons', Blackwell Science Ltd, vol. 3, no. 12, pp. 1669-1683. en_US
dc.identifier.issn 0950-382X en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8633
dc.description.abstract A family of novel mobile DNA elements is described, examples of which are found at several independent locations and encode a variety of antibiotic resistance genes. The complete elements consist of two conserved segments separated by a segment of variable length and sequence which includes inserted antibiotic resistance genes. The conserved segment located 3' to the inserted resistance genes was sequenced from Tn21 and R46, and the sequences are identical over a region of 2026 bases, which includes the sulphonamide resistance gene sull, and two further open reading frames of unknown function. The complete sequences of both the 3' and 5' conserved regions of the DNA element have been determined. A 59-base sequence element, found at the junctions of inserted DNA sequences and the conserved 3' segment, is also present at this location in the R46 sequence. A copy of one half of this 59-base element is found at the end of the sull gene, suggesting that sull, though part of the conserved region, was also originally inserted into an ancestral element by site-specific integration. Inverted or direct terminal repeats or short target site duplications, both of which are characteristics of class I and class II transposons, are not found at the outer boundaries of the elements described here. en_US
dc.language en_US
dc.publisher Blackwell Science Ltd en_US
dc.relation.isbasedon http://dx.doi.org/10.1111/j.1365-2958.1989.tb00153.x en_US
dc.title A Novel Family Of Potentially Mobile DNA Elements Encoding Site-Specific Gene-Integration Functions - Integrons en_US
dc.parent Molecular Microbiology en_US
dc.journal.volume 3 en_US
dc.journal.number 12 en_US
dc.publocation Oxford en_US
dc.identifier.startpage 1669 en_US
dc.identifier.endpage 1683 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 105741 en_US
dc.personcode 0000023354 en_US
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1989CH04400001 en_US
dc.description.keywords NA en_US
dc.staffid en_US


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