Synthesis of novel 30-spirocyclic-oxindole derivatives and assessment of their cytostatic activities

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dc.contributor.author Yong, Sarah en_US
dc.contributor.author Ung, Alison en_US
dc.contributor.author Pyne, Stephen en_US
dc.contributor.author Skelton, Brian en_US
dc.contributor.author White, Allan en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-05-28T09:43:27Z
dc.date.available 2010-05-28T09:43:27Z
dc.date.issued 2007 en_US
dc.identifier 2008005060 en_US
dc.identifier.citation Yong Sarah et al. 2007, 'Synthesis of novel 30-spirocyclic-oxindole derivatives and assessment of their cytostatic activities', Pergamon, vol. 63, no. 25, pp. 5579-5586. en_US
dc.identifier.issn 0040-4020 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/8481
dc.description.abstract The synthesis of some novel 3?-spirocyclic-oxindole compounds, based on the spiro[indole-3,5?-isoxazolidin]-2(1H)-one, the 2?H-spiro[indole-3,6?-[1,3]oxazinane]-2,2?(1H)-dione and the 2?H-spiro[indoline-3,3?-pyrrolo[1,2-c][1,3?]oxazine]-1?,2(1H)-dione heterocyclic structures, is described. These compounds were prepared from methyl ?-(2-nitrophenyl)acrylate via [1,3]-dipolar cycloaddition reactions with two acyclic nitrones and one cyclic nitrone followed by reduction of the cycloadducts and then treatment with triphosgene. Two of these compounds showed significant cytostatic activity on three cancer cell lines with GI50 values of 2.6?4.1 ?M on the human breast cancer cell line, MCF-7. en_US
dc.language en_US
dc.publisher Pergamon en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.tet.2007.04.028 en_US
dc.title Synthesis of novel 30-spirocyclic-oxindole derivatives and assessment of their cytostatic activities en_US
dc.parent Tetrahedron en_US
dc.journal.volume 63 en_US
dc.journal.number 25 en_US
dc.publocation United Kingdom en_US
dc.identifier.startpage 5579 en_US
dc.identifier.endpage 5586 en_US
dc.cauo.name SCI.Chemistry and Forensic Sciences en_US
dc.conference Verified OK en_US
dc.for 030500 en_US
dc.personcode 0000050295 en_US
dc.personcode 106546 en_US
dc.personcode 0000061573 en_US
dc.personcode 0000050291 en_US
dc.personcode 0000050292 en_US
dc.percentage 100 en_US
dc.classification.name Organic Chemistry en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US
dc.staffid en_US


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