Venomics: unraveling the complexity of animal venoms with mass spectrometry

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Show simple item record Escoubas, Pierre en_US Quinton, Loic en_US Nicholson, Graham en_US
dc.contributor.editor en_US 2010-05-28T09:43:18Z 2010-05-28T09:43:18Z 2008 en_US
dc.identifier 2007001378 en_US
dc.identifier.citation Escoubas Pierre, Quinton Loic, and Nicholson Graham 2008, 'Venomics: unraveling the complexity of animal venoms with mass spectrometry', John Wiley & Sons, Inc., vol. 43, no. 3, pp. 279-295. en_US
dc.identifier.issn 1076-5174 en_US
dc.identifier.other C1 en_US
dc.description.abstract Animal venoms and toxins are now recognized as major sources of bioactive molecules that may be tomorrowa??s new drug leads. Their complexity and their potential as drug sources have been demonstrated by application of modern analytical technologies, which have revealed venoms to be vast peptide combinatorial libraries. Structural aswell as pharmacological diversity is immense, andmass spectrometry is now one of the major investigative tools for the structural investigation of venom components. Recent advances in its use in the study of venom and toxins are reviewed. The application of mass spectrometry techniques to peptide toxin sequence determination by de novo sequencing is discussed in detail, in the light of the search for novel analgesic drugs. We also present the combined application of LC-MALDI separation with mass fingerprinting and ISD fragmentation for the determination of structural and pharmacological classes of peptides in complex spider venoms. This approach now serves as the basis for the full investigation of complex spider venom proteomes, in combination with cDNA analysis. en_US
dc.language en_US
dc.publisher John Wiley & Sons, Inc. en_US
dc.relation.isbasedon en_US
dc.title Venomics: unraveling the complexity of animal venoms with mass spectrometry en_US
dc.parent Journal of Mass Spectrometry en_US
dc.journal.volume 43 en_US
dc.journal.number 3 en_US
dc.publocation Hoboken, USA en_US
dc.identifier.startpage 279 en_US
dc.identifier.endpage 295 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 039900 en_US
dc.personcode 0000023295 en_US
dc.personcode 0000036757 en_US
dc.personcode 870145 en_US
dc.percentage 100 en_US Other Chemical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity ISI:000254270900001 en_US
dc.description.keywords mass spectrometry; venom; peptides; proteomics; MALDI-TOF; de novo sequencing; spider toxins en_US
dc.staffid 870145 en_US

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