Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase

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dc.contributor.author Wen, Suping en_US
dc.contributor.author Huang, Tom en_US
dc.contributor.author Li, George en_US
dc.contributor.author Yamahara, Johji en_US
dc.contributor.author Roufogalis, Basil en_US
dc.contributor.author Li, Yuhao en_US
dc.date.accessioned 2009-06-26T04:22:43Z
dc.date.available 2009-06-26T04:22:43Z
dc.date.issued 2006 en_US
dc.identifier 2005001957 en_US
dc.identifier.citation Wen Suping et al. 2006, 'Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase', Elsevier, vol. 78, no. 9, pp. 995-1002. en_US
dc.identifier.issn 0024-3205 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/818
dc.description.abstract Ileus continues to be a common consequence of abdominal surgery, causing significant patient discomfort and often leading to more serious problems. The therapy available is limited, hence, ileus remains an important clinical problem. Activation of inducible nitric oxide synthase (iNOS) directly modulates intestinal dysmotility after bowel manipulation and plays an essential role in initiating intestinal inflammation. Nuclear factor (NF) kB i sknown to be a critical component of iNOS gene transcriptional activation in response to inflammatory stimuli. Bromlain is an crude extract from the pineapply stem, which is sold as a nutritional supplement to promote digestive health and as an anti-inflammatory medication in some developed countries. Here we have found that oral administration of bromelain improves decrease in defecation in abdominal postoperative rats. Results showed that bromelain increased wet weight, dry weight, water content and number of fecal pellets in laparotomised plus mechanically manipulated rats, suggetsing imporvement of postoperative ileus. en_US
dc.publisher Elsevier en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.lfs.2005.06.007 en_US
dc.subject Bromelain. en
dc.subject Gastrointestinal dysmotility. en
dc.subject Ileus. en
dc.title Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase en_US
dc.parent Life Sciences en_US
dc.journal.volume 78 en_US
dc.journal.number 9 en_US
dc.publocation USA en_US
dc.identifier.startpage 995 en_US
dc.identifier.endpage 1002 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 060100 en_US
dc.personcode 010344 en_US
dc.personcode 0000021910 en_US
dc.personcode 0000025133 en_US
dc.personcode 0000021911 en_US
dc.personcode X000240 en_US
dc.personcode 0000021728 en_US
dc.percentage 100 en_US
dc.classification.name Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Bromelain, Ileus, Defecation, Inducible nitric Oxide synthase, Nuclear factor-kB en_US


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