Extracellular DNA Required For Bacterial Biofilm Formation

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dc.contributor.author Whitchurch, Cynthia en_US
dc.contributor.author Tolker-Nielsen, Tim en_US
dc.contributor.author Ragas, Pc en_US
dc.date.accessioned 2009-06-26T04:22:42Z
dc.date.available 2009-06-26T04:22:42Z
dc.date.issued 2002 en_US
dc.identifier 2008000883 en_US
dc.identifier.citation Whitchurch Cynthia et al. 2002, 'Extracellular DNA Required For Bacterial Biofilm Formation', Amer Assoc Advancement Science, vol. 295, no. 5559, pp. 1487-1487. en_US
dc.identifier.issn 0036-8075 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/815
dc.description.abstract Bacterial biofilms are structured communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface (1). Formation of these sessile communities and their inherent resistance to antibiotics and host immune attack are at the root of many persistent and chronic bacterial infections (1), including those caused by Pseudomonas aeruginosa, which has been intensively studied as a model for biofilm formation (2, 3). The matrix, which holds bacterial biofilms together, is a complex mixture of macromolecules including exopolysaccharides, proteins, and DNA (4). The latter has been presumed to be derived from lysed cells and has not been thought to represent an important component of biofilm structure. However, it has been known for many years that some bacteria, including P. aeruginosa, produce substantial quantities of extracellular DNA through a mechanism that is thought to be independent of cellular lysis and that appears to involve the release of small vesicles from the outer membrane en_US
dc.publisher Amer Assoc Advancement Science en_US
dc.relation.isbasedon http://dx.doi.org/10.1126/science.295.5559.1487 en_US
dc.title Extracellular DNA Required For Bacterial Biofilm Formation en_US
dc.parent Science en_US
dc.journal.volume 295 en_US
dc.journal.number 5559 en_US
dc.publocation Washington, USA en_US
dc.identifier.startpage 1487 en_US
dc.identifier.endpage 1487 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060501 en_US
dc.personcode 103745 en_US
dc.personcode 0000047380 en_US
dc.personcode 0000047381 en_US
dc.percentage 40 en_US
dc.classification.name Bacteriology en_US
dc.classification.type FOR-08 en_US
dc.location.activity ISI:000173981300042 en_US
dc.description.keywords Pseudomonas-aeruginosa en_US

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