Mechanism of ABC transporters: a molecular dynamics simulation of a well characterised nucleotide-binding subunit

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dc.contributor.author Jones, Peter en_US
dc.contributor.author George, Anthony en_US
dc.date.accessioned 2009-06-26T04:22:42Z
dc.date.available 2009-06-26T04:22:42Z
dc.date.issued 2002 en_US
dc.identifier 2004003003 en_US
dc.identifier.citation Jones Peter and George Anthony 2002, 'Mechanism of ABC transporters: a molecular dynamics simulation of a well characterised nucleotide-binding subunit', National Academy of Sciences, vol. 99, no. 20, pp. 12639-12644. en_US
dc.identifier.issn 1091-6490 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/811
dc.description.abstract ATP-binding cassette (ABC) transporters are membrane-bound molecular pumps that form one of the largest of all protein families. Several of them are central to phenomena of biomedical interest, including cystic fibrosis and resistance to chemotherapeutic drugs. ABC transporters share a common architecture comprising two hydrophilic nucleotide-binding domains (NBDs) and two hydrophobic transmembrane domains (TMDs) that form the substrate pathway across the membrane. The conformational changes in the NBDs induced by ATP hydrolysis and the means by which they are transmitted to the TMDs to effect substrate translocation remain largely unknown. We have performed a molecular dynamics simulation of HisP, the well studied NBD of the bacterial histidine permease, to identify hinges and switches of the NBD conformational transitions and subunit?subunit interfaces. en_US
dc.publisher National Academy of Sciences en_US
dc.title Mechanism of ABC transporters: a molecular dynamics simulation of a well characterised nucleotide-binding subunit en_US
dc.parent Proceedings of the National Academy of Sciences en_US
dc.journal.volume 99 en_US
dc.journal.number 20 en_US
dc.publocation USA en_US
dc.identifier.startpage 12639 en_US
dc.identifier.endpage 12644 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 110106 en_US
dc.personcode 020174 en_US
dc.personcode 860231 en_US
dc.percentage 50 en_US
dc.classification.name Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) en_US
dc.classification.type FOR-08 en_US
dc.description.keywords NA en_US
dc.staffid 860231 en_US


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