The integron/gene cassette system: an active player in bacterial adaptation

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dc.contributor.author Labbate, Maurizio en_US
dc.contributor.author Case, Rebecca en_US
dc.contributor.author Stokes, Hatch en_US
dc.contributor.editor M. Gogarten, P. Gogarten and L. Olendzenski en_US
dc.date.accessioned 2010-05-28T09:38:36Z
dc.date.available 2010-05-28T09:38:36Z
dc.date.issued 2009 en_US
dc.identifier 2009001238 en_US
dc.identifier.citation Labbate Maurizio, Case Rebecca, and Stokes Harold 2009, 'The integron/gene cassette system: an active player in bacterial adaptation', in http://dx.doi.org/10.1007/978-1-60327-853-9 (ed.), Humana Press, New York, pp. 103-125. en_US
dc.identifier.issn 978-1-60327-853-9 6 en_US
dc.identifier.other B1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/7892
dc.description.abstract The integron includes a site-specific recombination system capable of integrating and expressing genes contained in structures called mobile gene cassettes. Integrons were originally identified on mobile elements from pathogenic bacteria and were found to be a major reservoir of antibiotic-resistance genes. Integrons are now known to be ancient structures that are phylogenetically diverse and, to date, have been found in approximately 9 % of sequenced bacterial genomes. Overall, gene diversity in cassettes is extraordinarily high suggesting that the integron/gene cassette system has a broad role in adaptation rather than being confined to simply conferring resistance to antibiotics. In this chapter, we provide a review of the integron/gene cassette system highlighting characteristics associated with this system, diversity of elements contained within it and their importance in driving bacterial evolution and consequently adaptation. Ideas on the evolution of gene cassettes and gene cassette arrays are discussed. en_US
dc.language en_US
dc.publisher Humana Press en_US
dc.relation.isbasedon http://dx.doi.org/10.1007/978-1-60327-853-9 en_US
dc.title The integron/gene cassette system: an active player in bacterial adaptation en_US
dc.parent Horizontal Gene Transfer en_US
dc.journal.volume en_US
dc.journal.number en_US
dc.publocation New York en_US
dc.identifier.startpage 103 en_US
dc.identifier.endpage 125 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 106011 en_US
dc.personcode 0000058852 en_US
dc.personcode 105741 en_US
dc.percentage 100 en_US
dc.classification.name Gene and Molecular Therapy en_US
dc.classification.type FOR-08 en_US
dc.edition 1 en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Integron, gene cassette, antibiotic-resistance, attC en_US
dc.staffid 105741 en_US


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