Gold Nanosphere-Antibody Conjugates for Hyperthermal Therapeutic Applications

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Show simple item record Pissuwan, Dakrong en_US Cortie, C en_US Valenzuela, Stella en_US Cortie, Michael en_US 2009-06-26T04:13:10Z 2009-06-26T04:13:10Z 2007 en_US
dc.identifier 2006009233 en_US
dc.identifier.citation Pissuwan Dakrong et al. 2007, 'Gold Nanosphere-Antibody Conjugates for Hyperthermal Therapeutic Applications', World Gold Council, vol. 40, no. 2, pp. 121-129. en_US
dc.identifier.issn 1016-5339 en_US
dc.identifier.other C1 en_US
dc.description.abstract Gold nanoparticles can be conjugated with antibodies or other proteins, and the resulting composite particles will selectively attach to various kinds of biological material. Although exploitation of this for staining microscopy specimens is well known, there has recently been interest in attaching gold nanoparticles to live cells for therapeutic reasons. One motication is that gold nanoparticles display a strong plasmon resonance with light, which can be exploted in principle for an 'in vivo' photothermal therapy. The treatment of cancer by this technique has recently received attention by others, but here we show how gold nanoparticle based therapies can be developed to target live macrophage cells. We have employed 'active targeting' a scheme in which gold nanoparticles are functionalised with an antibody specific to the target macrophage cell. We describe how to prepare the conjugated particles, demonstrate that they will selectively attach 'in vitro' to their target macrophage cell but not to a non-target cell type and show that their presence renders the target cell susceptible to destruction by a low power laser. en_US
dc.publisher World Gold Council en_US
dc.title Gold Nanosphere-Antibody Conjugates for Hyperthermal Therapeutic Applications en_US
dc.parent Gold Bulletin en_US
dc.journal.volume 40 en_US
dc.journal.number 2 en_US
dc.publocation UK en_US
dc.identifier.startpage 121 en_US
dc.identifier.endpage 129 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 091200 en_US
dc.personcode 102551 en_US
dc.personcode 0000031903 en_US
dc.personcode 010690 en_US
dc.personcode 020302 en_US
dc.percentage 50 en_US Materials Engineering en_US
dc.classification.type FOR-08 en_US
dc.description.keywords NA en_US
dc.staffid 020302 en_US

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