Tethered bilayer membranes containing ionic reservoirs: Selectivity and conductance

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dc.contributor.author Krishna, Gowri en_US
dc.contributor.author Schulte, Jurgen en_US
dc.contributor.author Cornell, Bruce en_US
dc.contributor.author Pace, Ron en_US
dc.contributor.author Osman, Peter en_US
dc.date.accessioned 2009-06-26T04:10:56Z
dc.date.available 2009-06-26T04:10:56Z
dc.date.issued 2003 en_US
dc.identifier 2003000491 en_US
dc.identifier.citation Krishna Gowri et al. 2003, 'Tethered bilayer membranes containing ionic reservoirs: Selectivity and conductance', Amer Chemical Soc, vol. 19, no. 6, pp. 2294-2305. en_US
dc.identifier.issn 0743-7463 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/637
dc.description.abstract Ion channels, such as gramicidin A, selectively facilitate the transport of ions across biological and synthetic membranes. The conductance properties of ion channels are frequently characterized in synthetic bilayer lipid membranes (BLMs). The instability of BLMs has seriously limited the range of applications for these structures, and tethered bilayer lipid membranes (tBLMs) have addressed the problem through tethering many of the membrane components to a solid surface. In the present study, thin gold substrates have been used to tether thiol- and disulfide-terminated membrane components to form a tBLM electrode to provide a reservoir for ions. This study reports on the ion selectivity and apparent permeability of gramicidin channels in such tethered bilayer membranes. The investigations using electrical impedance spectroscopy indicated that the magnitude of ionic conductance varies substantially in reservoirs with different chemical structures. en_US
dc.publisher Amer Chemical Soc en_US
dc.relation.isbasedon http://dx.doi.org/10.1021/la026238d en_US
dc.title Tethered bilayer membranes containing ionic reservoirs: Selectivity and conductance en_US
dc.parent Langmuir en_US
dc.journal.volume 19 en_US
dc.journal.number 6 en_US
dc.publocation DC USA en_US
dc.identifier.startpage 2294 en_US
dc.identifier.endpage 2305 en_US
dc.cauo.name SCI.Physics and Advanced Materials en_US
dc.conference Verified OK en_US
dc.for 030600 en_US
dc.personcode 92050549 en_US
dc.personcode 960345 en_US
dc.personcode 0000020344 en_US
dc.personcode 0000020346 en_US
dc.personcode 0000020347 en_US
dc.percentage 100 en_US
dc.classification.name Physical Chemistry (incl. Structural en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Gramicidin-a Channel; Lipid-membranes; Transport; Model; Cytoplasm; Biosensor; Movements; Behavior; Kinetics; Analogs en_US

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