Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequences homology but not pharmacological properties with AVIT proteins

UTSePress Research/Manakin Repository

Search UTSePress Research


Advanced Search

Browse

My Account

Show simple item record

dc.contributor.author Wen, Suping en_US
dc.contributor.author Wilson, David en_US
dc.contributor.author Kuruppu, Sanjaya en_US
dc.contributor.author Korsinczky, Michael en_US
dc.contributor.author Hedrick, Joseph en_US
dc.contributor.author Pang, Ling en_US
dc.contributor.author Szeto, Tim en_US
dc.contributor.author Hodgson, Wayne en_US
dc.contributor.author Alewood, Paul en_US
dc.contributor.author Nicholson, Graham en_US
dc.date.accessioned 2009-06-26T04:10:53Z
dc.date.available 2009-06-26T04:10:53Z
dc.date.issued 2005 en_US
dc.identifier 2005001256 en_US
dc.identifier.citation Wen Suping et al. 2005, 'Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequences homology but not pharmacological properties with AVIT proteins', Elsevier Science, vol. 26, no. 12, pp. 2412-2426. en_US
dc.identifier.issn 0196-9781 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/593
dc.description.abstract This project identified a novel family of six 66-68 residue peptides fro the venom of two Australian funnerl-web spiders, Hadronyche sp. 20 and H. infesa: Orchid Beach (Hexathelidae: Atracinae), that appear to undergo N- and/or C-terminal post-translational modifications and conform to an ancestral prtein fold. These peptides all show significant amino acid sequence homology to atracotoxin-Hvf17 (ACTX-Hvf17), a non-toxic peptide isolated from the venom of H. versuta, and a variety of AVIT family proteins including mamba intestinal toxin 1 (MIT1) and its mammalian and piscine orthologs prokineticin 1 (PK1) and prokineticin 2 (PK2). en_US
dc.publisher Elsevier Science en_US
dc.relation.hasversion Accepted manuscript version en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.peptides.2005.05.012 en_US
dc.rights NOTICE: this is the author’s version of a work that was accepted for publication in Peptides. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Peptides, [Volume 26, Issue 12, December 2005, Pages 2412–2426] DOI# http://dx.doi.org/10.1016/j.peptides.2005.05.012 en_US
dc.title Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequences homology but not pharmacological properties with AVIT proteins en_US
dc.title.alternative Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequence homology but not pharmacological properties with AVIT family proteins en_US
dc.parent Peptides en_US
dc.journal.volume 26 en_US
dc.journal.number 12 en_US
dc.publocation New York, USA en_US
dc.identifier.startpage 2412 en_US
dc.identifier.endpage 2426 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 111500 en_US
dc.personcode 010344 en_US
dc.personcode 0000024019 en_US
dc.personcode 0000068867 en_US
dc.personcode 0000025163 en_US
dc.personcode 0000025164 en_US
dc.personcode 0000025165 en_US
dc.personcode 0000025166 en_US
dc.personcode WHODGSON en_US
dc.personcode 0000020342 en_US
dc.personcode 870145 en_US
dc.percentage 100 en_US
dc.classification.name Pharmacology and Pharmaceutical Sciences en_US
dc.classification.type FOR-08 en_US
dc.custom 2.511 en_US
dc.description.keywords ACTX-Hvf17; Mamba intestinal toxin 1; Bv8; Prokineticin, Funnel-web spider en_US
dc.staffid 870145 en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record