A deficiency in the in vivo clearance of apopototic cells is a feature of the NOD mouse

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dc.contributor.author O'Brien, Bronwyn en_US
dc.contributor.author Geng, Xuan en_US
dc.contributor.author Orteu, Catherine en_US
dc.contributor.author Huang, Yongqian en_US
dc.contributor.author Ghoreishi, Mehran en_US
dc.contributor.author Zhang, Yiqun en_US
dc.contributor.author Bush, Jason en_US
dc.contributor.author Li, Gang en_US
dc.contributor.author Finegood, Diane en_US
dc.contributor.author Dutz, Jan en_US
dc.date.accessioned 2009-12-21T02:34:54Z
dc.date.available 2009-12-21T02:34:54Z
dc.date.issued 2006 en_US
dc.identifier 2006006981 en_US
dc.identifier.citation O'Brien Bronwyn et al. 2006, 'A deficiency in the in vivo clearance of apopototic cells is a feature of the NOD mouse', Academic Press, vol. 26, pp. 104-115. en_US
dc.identifier.issn 0896-8411 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/4820
dc.description.abstract Deficiencies in apoptotic cell clearance have been linked to autoimmunity. Here we examined the time-course of peritoneal macrophage phagocytosis of dying cells following the direct injection of apoptotic thymocytes into the peritoneum of NOD mice and BALB/c controls. Macrophages from NOD mice demonstrated a profound defect in the phagocytosis of apoptotic thymocytes as compared to control macrophages. Nonobese diabetic mice also demonstrated a decrease in the clearance of apoptotic cell loads following an apoptotic stimulus to thymocytes (dexamethasone) when compared to BALB/c or NOR controls. Further, NOD mice demonstrated an increase in apoptotic cell load following an apoptotic stimulus to keratinocytes (ultraviolet light, UVB) when compared to control strains. Animals deficient in macrophage phagocytosis of apoptotic debris often manifest an autoimmune phenotype characterized by the production of antinuclear autoantibodies (ANA). We determined whether increased apoptotic cell loads (through repeated exposure to UVB irradiation) could accelerate such autoimmune phenomena in young NOD mice. Following repeated UVB irradiation, NOD mice, but not BALB/c or NOR controls, developed ANA. We propose that abnormalities in apoptotic cell clearance by macrophages predispose NOD mice to autoimmunity. en_US
dc.publisher Academic Press en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.jaut.2005.11.006 en_US
dc.title A deficiency in the in vivo clearance of apopototic cells is a feature of the NOD mouse en_US
dc.parent Journal of Autoimmunity en_US
dc.journal.volume 26 en_US
dc.journal.number en_US
dc.journal.number 2 en_US
dc.publocation United Kingdom en_US
dc.identifier.startpage en_US
dc.identifier.startpage 104 en_US
dc.identifier.endpage en_US
dc.identifier.endpage 115 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 110700 en_US
dc.personcode 030027 en_US
dc.personcode 0000030009 en_US
dc.personcode 0000030734 en_US
dc.personcode 0000030008 en_US
dc.personcode 0000030735 en_US
dc.personcode 0000030003 en_US
dc.personcode 0000030736 en_US
dc.personcode 0000023565 en_US
dc.personcode 0000030010 en_US
dc.personcode 0000030007 en_US
dc.percentage 100 en_US
dc.classification.name Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords clearance; macrophages; autoimmunity; diabetes; apoptosis en_US

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