Abstract:
Microarray technology is emerging as a powerful
method for the study of those changes in gene
expression that occur when a parasite converts from
one life cycle stage to another. The use of appropriate
experimental design and data analysis methodologies
is essential if this technology is to be correctly
exploited. In this review, the study of stage conversion
in the transformation of Toxoplasma gondiitachyzoites
into bradyzoites is considered as an example of where
the application of microarrays is revealing exciting new
knowledge on underlying molecular mechanisms. The
more general application of microarrays in parasitology
is also discussed.
