EEG Markers for Cognitive Decline in Elderly Subjects with subjective memory complaints

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dc.contributor.author Alexander, David en_US
dc.contributor.author Arns, Martijn en_US
dc.contributor.author Paul, Robert en_US
dc.contributor.author Rowe, Donald en_US
dc.contributor.author Cooper, Nicholas en_US
dc.contributor.author Esser, Aristide en_US
dc.contributor.author Fallahpour, Kamran en_US
dc.date.accessioned 2009-12-21T02:33:18Z
dc.date.available 2009-12-21T02:33:18Z
dc.date.issued 2006 en_US
dc.identifier 2006005496 en_US
dc.identifier.citation Alexander David et al. 2006, 'EEG Markers for Cognitive Decline in Elderly Subjects with subjective memory complaints', Imperial College Press, vol. 5, no. 1, pp. 49-74. en_US
dc.identifier.issn 0219-6352 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/4392
dc.description.abstract New treatments for Alzheimer's disease require early detection of cognitive decline. Most studies seeking to identify markers of early cognitive decline have focused on a limited number of measures. We sought to establish the profile of brain function measures which best define early neuropsychological decline. We compared subjects with subjective memory complaints to normative controls on a wide range of EEG derived measures, including a new measure of event-related spatio-temporal waves and biophysical modeling, which derives anatomical and physiological parameters based on subject's EEG measurements. Measures that distinguished the groups were then related to cognitive performance on a variety of learning and executive function tasks. The EEG measures include standard power measures, peak alpha frequency, EEG desynchronization to eyes-opening, and global phase synchrony. The most prominent differences in subjective memory complaint subjects were elevated alpha power and an increased number of spatio-temporal wave events. Higher alpha power and changes in wave activity related most strongly to a decline in verbal memory performance in subjects with subjective memory complaints, and also declines in maze performance and working memory reaction time. Interestingly, higher alpha power and wave activity were correlated with improved performance in reverse digit span in the subjective memory complaint group. The modeling results suggest that differences in the subjective memory complaint subjects were due to a decrease in cortical and thalamic inhibitory gains and slowed dendritic time-constants. The complementary profile that emerges from the variety of measures and analyses points to a nonlinear progression in electrophysiological changes from early neuropsychological decline to late-stage dementia, and electrophysiological changes in subjective memory complaint that vary in their relationships to a range of memory-related tasks. en_US
dc.publisher Imperial College Press en_US
dc.title EEG Markers for Cognitive Decline in Elderly Subjects with subjective memory complaints en_US
dc.parent Journal of Integrative Neuroscience en_US
dc.journal.volume 5 en_US
dc.journal.number 1 en_US
dc.publocation UK en_US
dc.identifier.startpage 49 en_US
dc.identifier.endpage 74 en_US
dc.cauo.name FEIT.School of Systems, Management and Leadership en_US
dc.conference Verified OK en_US
dc.for 110903 en_US
dc.personcode 0000023008 en_US
dc.personcode 0000028689 en_US
dc.personcode 0000028690 en_US
dc.personcode 0000028691 en_US
dc.personcode 0000028514 en_US
dc.personcode 0000028692 en_US
dc.personcode 0000028693 en_US
dc.percentage 100 en_US
dc.classification.name Central Nervous System en_US
dc.classification.type FOR-08 en_US
dc.description.keywords subjective memory, complaint, cognition, EEG en_US


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