Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs

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dc.contributor.author Chan, Yannie en_US
dc.contributor.author Bulmus, Volga en_US
dc.contributor.author Zareie, Hadi en_US
dc.contributor.author Byrne, Frances en_US
dc.contributor.author Barner, Leonie en_US
dc.contributor.author Kavallaris, Maria en_US
dc.date.accessioned 2009-12-21T02:32:15Z
dc.date.available 2009-12-21T02:32:15Z
dc.date.issued 2006 en_US
dc.identifier 2006004638 en_US
dc.identifier.citation Chan Yannie et al. 2006, 'Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs', Elsevier, vol. 115, pp. 197-207. en_US
dc.identifier.issn 0168-3695 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/4209
dc.description.abstract Here we describe the combined use of acid-labile microgel approach and RAFT-mediated seeded despersion polymerisation technique to prepare an acid-cleavable core-shell like polymeric colloidal system for the delivery of hydrophobic drugs at slightly acidic sites. A new bisacrylate acetal crosslinker was copolymerised with n-butyl acrylate (BA) in the presence of a RAFT agent using a dispersion polymerisation technique, which yieled crosslinked spherical particles with the size ranging between 150 and 500 nm. The particles were cleaved in a pH-dependent manner similar to the acid-labile hydrolysis behaviour of the crosslinker. In order to mask the hydrophobic surface of the particles, polyethelene glycol acrylate (PEG-A) was grafted onto poly(BA) seed particles via the RAFT agent groups on the particle surface. The acidic-site selective delivery protential of the poly(BA)-g-poly(PEG-A) particles was assessed in-vitro using a lipophilic flueorescent dye as a model hydrophobic drug. Ca. 73% and 34% of the total dye loaded in the paerticles was found to be released at pH 5.0 and 7.4 in 24h, respectively. Thegrowth of human neuroblastoma cells was not affected by the incubation with the core-shell particles and their cleavage by-products upto 3 mg/ml concentration. The physiocochemical and the functional features support the potential value of the acid-cleavable poly(BA) core-poly(PEG-A) shell particles as carriers for the delivery of hydrophobic drugs at acidic sites. en_US
dc.publisher Elsevier en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.jconrel.2006.07.025 en_US
dc.title Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs en_US
dc.parent Journal of Controlled Release en_US
dc.journal.volume 115 en_US
dc.journal.number 2 en_US
dc.publocation Amsterdam, the Netherlands en_US
dc.identifier.startpage 197 en_US
dc.identifier.endpage 207 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 090399 en_US
dc.personcode 0000028406 en_US
dc.personcode 0000028407 en_US
dc.personcode 030414 en_US
dc.personcode 0000028408 en_US
dc.personcode 0000028409 en_US
dc.personcode 0000028410 en_US
dc.percentage 100 en_US
dc.classification.name Biomedical Engineering not elsewhere classified en_US
dc.classification.type FOR-08 en_US
dc.description.keywords pH-sensitive particles; drug delivery; PEG grafting; despersion polymerisation; reversible addition-fragmentaion chain transfer (RAFT) en_US


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