Irritable bowel syndrome: A review on the role of intestinal protozoa and the importance of their detection and diagnosis

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dc.contributor.author Stark, Damien en_US
dc.contributor.author Van Hal, Sebastiaan en_US
dc.contributor.author Marriott, Debbie en_US
dc.contributor.author Ellis, John en_US
dc.contributor.author Harkness, Jock en_US
dc.date.accessioned 2009-12-21T02:30:44Z
dc.date.available 2009-12-21T02:30:44Z
dc.date.issued 2007 en_US
dc.identifier 2006008505 en_US
dc.identifier.citation Stark Damien et al. 2007, 'Irritable bowel syndrome: A review on the role of intestinal protozoa and the importance of their detection and diagnosis', Elsevier Inc, vol. 37, no. 1, pp. 11-20. en_US
dc.identifier.issn 0020-7519 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/3912
dc.description.abstract Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which abdominal pain is associated with a defect or a change in bowel habits. Gut inflammation is one of the proposed mechanisms of pathogenesis. Recent studies have described a possible role for protozoan parasites, such as Blastocystis hominis and Dientamoeba fragilis, in the etiology of IBS. Dientamoeba fragilis is known to cause IBS-like symptoms and has a propensity to cause chronic infections but its diagnosis relies on microscopy of stained smears, which many laboratories do not perform, thereby leading to the misdiagnosis of dientamoebiasis as IBS. The role of B. hominis as an etiological agent of IBS is inconclusive, due to contradictory reports and the controversial nature of B. hominis as a human pathogen. Although Entamoeba histolytica infections occur predominately in developing regions of the world, clinical diagnosis of amebiasis is often difficult because symptoms of patients with IBS may closely mimic those patients with non-dysenteric amoebic colitis. Clinical manifestations of Giardia intestinalis infection also vary from asymptomatic carriage to acute and chronic diarrhoea with abdominal pain. These IBS-like symptoms can be continuous, intermittent, sporadic or recurrent, sometimes lasting years without correct diagnosis. It is essential that all patients with IBS undergo routine parasitological investigations in order to rule out the presence of protozoan parasites as the causative agents of the clinical signs. en_US
dc.publisher Elsevier Inc en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.ijpara.2006.09.009 en_US
dc.title Irritable bowel syndrome: A review on the role of intestinal protozoa and the importance of their detection and diagnosis en_US
dc.parent International Journal For Parasitology en_US
dc.journal.volume 37 en_US
dc.journal.number 1 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 11 en_US
dc.identifier.endpage 20 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 104964 en_US
dc.personcode 0000031263 en_US
dc.personcode 100209 en_US
dc.personcode 910945 en_US
dc.personcode 100210 en_US
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.staffid 100210 en_US


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