Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections

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dc.contributor.author Rashid, Rebecca en_US
dc.contributor.author Tabata, Tami en_US
dc.contributor.author Oatley, Melissa en_US
dc.contributor.author Besser, Thomas en_US
dc.contributor.author Tarr, Phillip en_US
dc.contributor.author Moseley, Steve en_US
dc.date.accessioned 2009-12-21T02:30:18Z
dc.date.available 2009-12-21T02:30:18Z
dc.date.issued 2006 en_US
dc.identifier 2006006650 en_US
dc.identifier.citation Rashid Rebecca et al. 2006, 'Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections', Amer Soc Microbiology, vol. 74, no. 7, pp. 4142-4148. en_US
dc.identifier.issn 0019-9567 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/3826
dc.description.abstract Escherichia coli O157:H7 is a commensal organism in cattle, but it is a pathogen in humans. This differential expression of virulence suggests that specific virulence factors are regulated differently in human and bovine hosts. To test this hypothesis, relative real-time reverse transcription-PCR was used to relate the expression of several putative virulence genes (eae, espA, stx2, rfbE, ehxA, and iha) to that of the "housekeeping" gene gnd during natural human and experimental bovine infection with E. coli O157:H7. We examined these genes in fecal samples from eight humans and four calves. iha and espA were significantly more expressed in bovine infections. rfbE and ehxA appeared to be more highly expressed in human infections, though these differences did not achieve statistical significance. Our results support the hypothesis that some virulence-associated genes of O157:H7 are differentially expressed in a host-specific manner. en_US
dc.publisher Amer Soc Microbiology en_US
dc.relation.isbasedon en_US
dc.relation.isbasedon http://dx.doi.org/10.1128/IAI.00299-06 en_US
dc.title Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections en_US
dc.parent Infection And Immunity en_US
dc.journal.volume 74 en_US
dc.journal.number 7 en_US
dc.publocation Washington DC, USA en_US
dc.identifier.startpage 4142 en_US
dc.identifier.endpage 4148 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 100098 en_US
dc.personcode 0000036742 en_US
dc.personcode 0000036743 en_US
dc.personcode 0000036744 en_US
dc.personcode 0000033931 en_US
dc.personcode 0000033932 en_US
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US


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