Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

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dc.contributor.author Rashid, Imran en_US
dc.contributor.author Van Reyk, David en_US
dc.contributor.author Davies, Michael en_US
dc.date.accessioned 2009-12-21T02:30:10Z
dc.date.available 2009-12-21T02:30:10Z
dc.date.issued 2007 en_US
dc.identifier 2006008478 en_US
dc.identifier.citation Rashid Imran, Van Reyk David, and Davies Michael 2007, 'Carnosine and its constituents inhibit glycation of low-density lipoproteins that promote foam cell formation in vitro', Elsevier, vol. 581, pp. 1067-1070. en_US
dc.identifier.issn 0014-5793 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/3775
dc.description.abstract Gycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can resultin the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosis, or its constituent amino acids beta-alanine and L-histidine, can inhibit the modification of LDL by glycolaldehyde when prsent at equimolar concentrations to the modifying agent,. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. This carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis. en_US
dc.publisher Elsevier en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.febslet.2007.01.082 en_US
dc.title Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro en_US
dc.parent FEBS Letters en_US
dc.journal.volume 581 en_US
dc.journal.number 5 en_US
dc.publocation Netherlands en_US
dc.identifier.startpage 1067 en_US
dc.identifier.endpage 1070 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060100 en_US
dc.personcode 0000028295 en_US
dc.personcode 000788 en_US
dc.personcode 0000045917 en_US
dc.percentage 100 en_US
dc.classification.name Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords Atherisclerosis, Aldehyde, Carnosine, Foam cell, Glycation, Low-density lipoprotein en_US


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