The ABC transporter structure and mechanism: perspectives on recent research

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Show simple item record Jones, Peter en_US George, Anthony en_US 2009-12-21T02:30:00Z 2009-12-21T02:30:00Z 2004 en_US
dc.identifier 2004000812 en_US
dc.identifier.citation Jones Peter and George Anthony 2004, 'The ABC transporter structure and mechanism: perspectives on recent research', Birkhauser Verlag, vol. 61, pp. 682-699. en_US
dc.identifier.issn 1420-682X en_US
dc.identifier.other C1 en_US
dc.description.abstract ATP-binding cassetee (ABC) transporters are multidomain integral membrane proteins that utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all phyla. ABC transporters form one of the largest of all protein families and are central to many important biomedical phenomena, including resistance of cancers and pathogenic mocribes to drugs. Elucidation of the sturcture and mechanism of ABC transporters is essential to the rational design of agents to control their fuctiom. While a wealth of high-resolution structures of ABC proteins have been produced in recent years, many fundamental questions regarding the protein's mechanism remain unasnwered. I this review, we examine the recent structural data concerning ABC transporters and related proteins in te ligh of other experimental and theoretical data, and discuss these data in relation to current ideas concerning the transporters' molecular mechanism. en_US
dc.publisher Birkhauser Verlag en_US
dc.relation.isbasedon en_US
dc.title The ABC transporter structure and mechanism: perspectives on recent research en_US
dc.parent Cellular and Molecular Life Sciences en_US
dc.journal.volume 61 en_US
dc.publocation Besel en_US
dc.identifier.startpage 682 en_US
dc.identifier.endpage 699 en_US SCI.Environmental Sciences en_US
dc.conference Verified OK en_US
dc.for 060100 en_US
dc.personcode 020174 en_US
dc.personcode 860231 en_US
dc.percentage 100 en_US Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.description.keywords ABC transporter; ABC-ATPase; membrane trasport; nucelotide-binding domain; ATP hydrolysis; mechanisms; P-glycoprotein en_US
dc.staffid 860231 en_US

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