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Enhanced invasive properties exhibited by smooth muscle cells are associated with elevated production of MMP-2 in patients with aortic aneurysms

Goodall Stephen; Porter K; Bell P; Thompson Matt (WB Saunders Co. Ltd., 2002)

Background: abdominal aortic aneurysms (AAA) are associated with excessive vascular matrix remodelling. Recent findings suggest a systemic overproduction of matrix metalloproteinases-2 (MMP-2) by vascular smooth muscle ...
Prospective, randomised, double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques

Axisa A; Loftus Im; Naylor Ar; Goodall Stephen; Jones L; Bell P; Thompson Matt (Lippincott Williams & Wilkins, 2002)

Background and Purpose¿Elevated levels of matrix metalloproteinases (MMPs), particularly MMP-1 and MMP-9, have been implicated in plaque rupture. It has been suggested that inhibition of MMPs may stabilize vulnerable ...

Now showing items 1-2 of 2