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Abnormal Myocardial Contraction In Alpha(1A)- And Alpha(1B)-Adrenoceptor Double-Knockout Mice

Mccloskey Dt; Turnbull Lynne; Swigart P; O'Connell T; Simpson Pc; Baker Anthony (Academic Press Ltd Elsevier Science Ltd, 2003)

We used double-knockout mice (ABKO) lacking both predominant myocardial alpha(1)-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) to determine if alpha(1)-ARs are required for normal myocardial contraction. ...
Alpha(1)-Adrenergic Receptor Responses In Alpha(1AB)-AR Knockout Mouse Hearts Suggest The Presence Alpha(1D)-AR

Turnbull Lynne; Mccloskey Dt; O'Connell T; Simpson Pc; Baker Anthony (Amer Physiological Soc, 2003)

Two functional (xi-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) have been identified in the mouse heart. However, it is unclear whether the third known subtype, alpha(1D)-AR, is also present. To investigate ...
Alpha(1)-Adrenergic Receptors Prevent A Maladaptive Cardiac Response To Pressure Overload

O'Connell T; Swigart Pm; Rodrigo Mc; Ishizaka S; Joho S; Turnbull Lynne; Tecott Lh; Baker Anthony; Foster E; Grossman W; Simpson Pc (Amer Soc Clinical Investigation Inc, 2006)

An alpha(1)-adrenergic receptor (alpha(1)-AR) antagonist increased heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), but it is unknown whether this adverse result ...

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