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Browsing 07 Agricultural and Veterinary Sciences by Author

Browsing 07 Agricultural and Veterinary Sciences by Author "Robinson Mark"

Now showing items 1-7 of 7

Cysteine Proteases of Pathogenic Organisms

Stack Colin; Dalton John; Robinson Mark (Springer, 2011)

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The effect of the microtubule inhibitor tubulozole-C on the tegument of triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica

Robinson Mark; Trudgett A; Hoey Elizabeth; Fairweather I (Springer, 2003)

The benzimidazole derivative, triclabendazole is the main drug used against Fasciola hepatica, although its precise mode of action remains to be fully determined. Previous studies have suggested that triclabendazole acts ...
The enigmatic asparaginyl endopeptidase of helminth parasites

Dalton John; Brindley Paul; Donnelly Sheila; Robinson Mark (Cell Press, 2009)

The clan CD cysteine protease of Schistosoma mansoni (SmAE, also known as Sm32 or schistosome legumain) is an asparaginyl endopeptidase that cleaves C-terminal to asparaginyl (Asn) residues. The enzyme was considered to ...
The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

Lowther Jonathan; Robinson Mark; Donnelly Sheila; Xu Weibo; Stack Colin; Matthews J; Dalton John (Public Library Science, 2009)

The helminth parasite Fasciola hepatica secretes cathepsin L cysteine proteases to invade its host, migrate through tissues and digest haemoglobin, its main source of amino acids. Here we investigated the importance of pH ...
Micro-environmental conditions modulate protein secretion and infectivity of the Trichinella spiralis L1 larva.

Bolas-Fernandez Franscisco; Dea-Ayuela Maria; Connolly Bernadette; Robinson Mark (Elsevier Inc, 2009)

After digestion of infected meat the free L1 of Trichinella spp. penetrate the intestinal mucosa where they moult to the mature adult stage. We have used proteomics to identify changes in protein secretion during in vitro ...
The occurrence and significance of triploidy in the liver fluke, Fasciola hepatica. Parasitology

Fletcher Hugh; Hoey Elizabeth; Orr Nick; Trudgett A; Fairweather I; Robinson Mark (Cambridge University Press, 2004)

Karyotyping of Fasciola hepatica samples from Britain and Ireland has identified a triploid isolate which is effectively aspermic, rendering it necessarily asexually reproducing. Considering the extensive presence of ...
Profiling excretory-secretory proteins of Trichinella muscle larvae by 2-dimensional gel electrophoresis and mass spectrometry

Robinson Mark; Gare Dan; Connolly Bernadette (Elsevier, 2005)

Infection of mammalian skeletal muscle with the intracellular parasite Trichinella spiralis results in profound alterations in the host cell and a realignment of host cell gene expression. The role of parasite excretory/secretory ...

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Browsing 07 Agricultural and Veterinary Sciences by Author "Robinson Mark"

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Browsing 07 Agricultural and Veterinary Sciences by Author "Robinson Mark"