Fasciola hepatica: The therapeutic potential of a worm secretome

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dc.contributor.author Robinson, Mark en_US
dc.contributor.author Dalton, John en_US
dc.contributor.author O'Brien, Bronwyn en_US
dc.contributor.author Donnelly, Sheila en_US
dc.contributor.editor en_US
dc.date.accessioned 2014-04-03T01:53:21Z
dc.date.available 2014-04-03T01:53:21Z
dc.date.issued 2013 en_US
dc.identifier 2011008653 en_US
dc.identifier.citation O'Brien, Bronwyn et al. 2013, 'Fasciola hepatica: The therapeutic potential of a worm secretome', International Journal for Parasitology, vol. 43, no. 3-4, pp. 283-291. en_US
dc.identifier.issn 0020-7519 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/23431
dc.description.abstract The success of helminth parasites is partly related to their ability to modulate host immune responses towards an anti-inflammatory/regulatory phenotype. This ability resides with the molecules contained in the secretome of various helminths that have been shown to interact with host immune cells and influence their function. Consequently, there exists a unique opportunity to exploit these molecules for the prophylactic and therapeutic treatment of human pro- and auto-inflammatory disorders (for example septic shock, transplant rejection and autoimmune disease). In this review, we describe the mechanisms used by the trematode parasite, Fasciola hepatica, to modulate the immune responses of its host and discuss the potent immune-modulatory effects of three individual molecules within the secretome; namely cathepsin L1, peroxiredoxin and helminth defence molecule. With a focus on the requirements from industry, we discuss the strategies by which these molecules may be clinically developed to control human immune responses in a way that is conducive to the prevention of immune-mediated diseases. en_US
dc.language en_US
dc.publisher Elsevier Inc en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.ijpara.2012.11.004 en_US
dc.title Fasciola hepatica: The therapeutic potential of a worm secretome en_US
dc.parent International Journal For Parasitology en_US
dc.journal.volume 43 en_US
dc.journal.number 3-4 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 283 en_US
dc.identifier.endpage 291 en_US
dc.cauo.name SCI.School of Medical and Molecular Sciences en_US
dc.conference Verified OK en_US
dc.for 070700 en_US
dc.personcode 100777 en_US
dc.personcode 030896 en_US
dc.personcode 030027 en_US
dc.personcode 995261 en_US
dc.percentage 100 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Fasciola hepatica; Cysteine protease; Peroxiredoxin; Helminth defence molecule; Macrophage; Diabete en_US
dc.staffid 995261 en_US

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