Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung

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dc.contributor.author Haghi, Mehra en_US
dc.contributor.author Young, Paul en_US
dc.contributor.author Traini, Daniela en_US
dc.contributor.author Bebawy, Mary en_US
dc.contributor.editor R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, S.J. Farr and P.M. Young en_US
dc.date.accessioned 2014-04-03T01:24:29Z
dc.date.available 2014-04-03T01:24:29Z
dc.date.issued 2010 en_US
dc.identifier 2012002983 en_US
dc.identifier.citation Young, Paul et al. 2010, 'Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung', Davis Healthcare Int', Illnois USA, pp. 875-878. en_US
dc.identifier.issn 1-933722-41-X en_US
dc.identifier.other E1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/23204
dc.description.abstract Calu-3, a sub-bronchial epithelial cell line, cultured at the air-interfaced, has been shown to be a very reliable model for the in vitro investigation of inhalation drug delivery to the upper airways. It has been found to be superior with respect to morphology and function when compared to the liquid covered culture model (1, 2), but the Calu-3 air-interface model has not been fully investigated for P-glycoprotein (P-gp) expression (3, 4) ? a parameter that could influence predicted drug delivery in the lung. P-gp is a plasma membrane drug transporter, actively involved in `carrying? a wide range of structurally and functionally unrelated drugs out of cells (5). P-gp has been shown to interact with some drugs routinely used in respiratory therapy (1). Another factor that may affect drug transport across the epithelium is the presence of mucus; which, in healthy lungs, aids mucociliary clearance of deposited particulate matter, acts as an antibacterial substance and prevents loss of excessive fluid from the airway due to evaporation (6). The aim of this investigation was to characterize mucus secretion and cell surface P-gp expression and function in the Calu-3 air-interface model. en_US
dc.language en_US
dc.publisher Davis Healthcare Int' en_US
dc.relation.isbasedon NA en_US
dc.title Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung en_US
dc.parent Proceedings of Respiratory Drug Delivery 2010 en_US
dc.journal.volume 3 en_US
dc.journal.number en_US
dc.publocation Illnois USA en_US
dc.identifier.startpage 875 en_US
dc.identifier.endpage 878 en_US
dc.cauo.name GSH.Pharmacy en_US
dc.conference Verified OK en_US
dc.for 111500 en_US
dc.personcode 0000076235 en_US
dc.personcode 121357 en_US
dc.personcode 121355 en_US
dc.personcode 112474 en_US
dc.percentage 100 en_US
dc.classification.name Pharmacology and Pharmaceutical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom Respiratory Drug Delivery 2010 en_US
dc.date.activity 20100425 en_US
dc.location.activity Orlando, Florida en_US
dc.description.keywords respiratory epithelium, Calu-3, P-glycoprotein (P-gp), permeability, efflux en_US
dc.staffid 112474 en_US


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