Browsing Closed by Author "Baker, Anthony"

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Browsing Closed by Author "Baker, Anthony"

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  • Mccloskey, Dt; Turnbull, Lynne; Swigart, P; O'Connell, T; Simpson, Pc; Baker, Anthony (Academic Press Ltd Elsevier Science Ltd, 2003)
    We used double-knockout mice (ABKO) lacking both predominant myocardial alpha(1)-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) to determine if alpha(1)-ARs are required for normal myocardial contraction. ...
  • Turnbull, Lynne; Mccloskey, Dt; O'Connell, T; Simpson, Pc; Baker, Anthony (Amer Physiological Soc, 2003)
    Two functional (xi-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) have been identified in the mouse heart. However, it is unclear whether the third known subtype, alpha(1D)-AR, is also present. To investigate ...
  • O'Connell, T; Swigart, P; Rodrigo, Mc; Ishizaka, S; Joho, S; Turnbull, Lynne; Tecott, Lh; Baker, Anthony; Foster, E; Grossman, W; Simpson, Pc (Amer Soc Clinical Investigation Inc, 2006)
    An alpha(1)-adrenergic receptor (alpha(1)-AR) antagonist increased heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), but it is unknown whether this adverse result ...
  • Mccloskey, Dt; Turnbull, Lynne; Swigart, P; Zambon, Ac; Turcato, S; Joho, S; Grossman, W; Conklin, Br; Simpson, Pc; Baker, Anthony (Amer Physiological Soc, 2005)
    The cardiac-specific tetracycline-regulated gene expression system (tet-system) is a powerful tool using double-transgenic mice. The cardiac alpha-myosin heavy chain promoter (alpha MHC) drives lifetime expression of a ...
  • Turcato, S; Turnbull, Lynne; Wang, Guan-Ying; Honbo, N; Simpson, Pc; Karliner, Js; Baker, Anthony (Dr Dietrich Steinkopff Verlag, 2006)
    The goal of this study was to determine if an ischemic preconditioning (IPC) protocol improved post-ischemic functional recovery of female mouse hearts. A previous study found that IPC did not occur in hearts from 10-week-old ...
  • Turnbull, Lynne; Zhou, Hong; Swigart, P; Turcato, S; Karliner, Js; Conklin, Br; Simpson, Pc; Baker, Anthony (Amer Physiological Soc, 2006)
    Preconditioning protocols that protect the heart from ischemic injury may aid in the development of new therapies. However, the temporal window of cardioprotection is limited to a few days after the preconditioning stimulus. ...