GRP78 is a major protein regulated by the mammalian endoplasmic reticulum stress response, and up-regulation has been shown to be important in protecting cells from challenge with cytotoxic agents. GRP78 has ATPase activity, ...

Macrophages are capable of killing tumor cells by releasing nitric oxide (NO) and reactive nitrogen species after expression of the inducible nitric oxide synthase (iNOS) gene. We intend to develop a novel cell-based therapy ...

In previous studies, we found multiple copies of inducible nitric oxide synthase gene (NOS2)-like sequences in the human genome and mapped them to the pericentric region of chromosome 17. Here, we describe the cloning and ...