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Browsing 06 Biological Sciences by Author "Lamb Heather"

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The Affinity of a Major Ca2+ Binding Site on GRP78 Is Differentially Enhanced by ADP and ATP

Lamb Heather; Mee Christopher; Xu Weiming; Liu Lizhi; Blond Sylvie; Cooper Alan; Charles Ian; Hawkins Alastair (ASBMB, 2006)

GRP78 is a major protein regulated by the mammalian endoplasmic reticulum stress response, and up-regulation has been shown to be important in protecting cells from challenge with cytotoxic agents. GRP78 has ATPase activity, ...
Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351

Stamp Anna; Owen Paul; El Omari Kamel; Lockyer Michael; Lamb Heather; Charles Ian; Hawkins Alastair; Stammers David (Wiley-Liss, 2011)

Periplasmic binding proteins (PBPs) are crucial transport system components of prokaryotes, required for bacterial growth and survival. PBPs are also used by Gram negative bacteria for small molecule active transport via ...
Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinases from Salmonella typhi and Mycobacterium tuberculosis

Moore Jonathan; Lamb Heather; Garbe Thomas; Servos Spiros; Dougan Gordon; Charles Ian; Hawkins Alastair (Portland Press, 1992)

The aroQ gene of Mycobacterium tuberculosis, encoding a type-II 3-dehydroquinase, and the aroD gene of Salmonella typhi, encoding a type-I 3-dehydroquinase, have been highly overexpressed in Escherichia coli using the ...
The pre-chorismate (shikimate) and quinate pathways in filamentous fungi : theoretical and practical aspects

Hawkins Alastair; Lamb Heather; Moore Jonathan; Charles Ian; Roberts Clive (Soc General Microbiology, 1993)

The detailed chemistry and enzymology of the shikimate pathway have been extensively discussed in recent excellent reviews (Pittard, 1987 ; Bentley, 1990 ; Braus, 1991). This short review will therefore focus ( a ) on the ...
Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium

Nichols Charlie; Johnson C.; Lamb Heather; Lockyer Michael; Charles Ian; Hawkins Alastair; Stammers David (Blackwell Publishing, 2007)

The YjeQ class of P-loop GTPases assist in ribosome biogenesis and also bind to the 30S subunit of mature ribosomes. YjeQ ribosomal binding is GTP-dependent and thought to specifically direct protein synthesis, although ...

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Browsing 06 Biological Sciences by Author "Lamb Heather"

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Browsing 06 Biological Sciences by Author "Lamb Heather"