Browsing 06 Biological Sciences by Author "Gardiner, Donald"

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Browsing 06 Biological Sciences by Author "Gardiner, Donald"

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  • Maric, Selma; Donnelly, Sheila; Robinson, Mark; Skinner-Adams, Tina; Trenholme, Katharine; Gardiner, Donald; Dalton, John; Stack, Colin; Lowther, Jonathan (Amer Chemical Soc, 2009)
    The M17 leucine aminopeptidase of the intraerythrocytic stages of the malaria parasite Plasmodium falciparum (PfLAP) plays it role in releasing amino acids from host hemoglobin that are used for parasite protein synthesis, ...
  • Mcgowan, Sheena; Porter, Corinne; Lowther, Jonathan; Stack, Colin; Golding, Sarah; Skinner-Adams, Tina; Trenholme, Katharine; Teuscher, Franka; Donnelly, Sheila; Grembecka, Jolanta; Mucha, Artur; Kafarski, Pawel; Degori, Ross; Buckle, Ashley; Gardiner, Donald; Whisstock, James; Dalton, John (National Academy of Sciences of the United States of America, 2009)
    Plasmodium falciparum parasites are responsible for the major global disease malaria, which results in >2 million deaths each year. With the rise of drug-resistant malarial parasites, novel drug targets and lead compounds ...
  • Sivaraman, Kk; Oellig, Ca; Huynh, Kitmun; Atkinson, Sc; Poreba, M; Perugini, Matthew; Trenholme, Katharine; Gardiner, Donald; Salvesen, G; Drag, M; Dalton, John; Whisstock, James; Mcgowan, Sheena (Academic Press Ltd- Elsevier Science Ltd, 2012)
    The malarial aminopeptidases have emerged as promising new drug targets for the development of novel antimalarial drugs. The M18AAP of Plasmodium falciparum malaria is a metallo-aminopeptidase that we show demonstrates a ...