Browsing 03 Chemical Sciences by Author "Taylor Dennis"

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Browsing 03 Chemical Sciences by Author "Taylor Dennis"

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  • Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines 
    Macreadie Ian; Avery Thomas; Robinson Tony; Macreadie Peter; Barraclough Miles; Taylor Dennis; Tiekink Edward (Pergamon, 2008)
    In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure¿activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and ...
  • Design of endoperoxides with anti-Candida activity 
    Avery Thomas; Macreadie Peter; Greatrex Ben; Robinson Tony; Taylor Dennis; Macreadie Ian (Pergamon, 2007)
    Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity ...
  • Novel endoperoxide antimalarials: Synthesis, heme binding, and antimalarial activity 
    Taylor Dennis; Avery Thomas; Greatrex Ben; Tiekink Edward; Macreadie Ian; Macreadie Peter; Humphries Adam; Kalkanidis Martha; Fox Emma; Klonis Nectarios; Tilley Leann (American Chemical Society, 2004)
    We report the synthesis of a series of novel epoxy endoperoxide compounds that can be prepared in high yields in one to three steps from simple starting materials. Some of these compounds inhibit the growth of Plasmodium ...
  • Novel endoperoxides: Synthesis and activity against Candida species 
    Macreadie Peter; Avery Thomas; Greatrex Ben; Taylor Dennis; Macreadie Ian (Pergamon, 2006)
    A series of novel endoperoxides were synthesised and tested for inhibitory activity against Candida growth. Despite structural similarities, their activity varied considerably. Several endoperoxides demonstrated potential ...