Oxidation of MDMA in urine after exposure to bleach

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dc.contributor.author Pham, Annie en_US
dc.contributor.author Fu, Shanlin en_US
dc.contributor.author Dawson, Michael en_US
dc.contributor.editor Dimitri Gerostamoulos; Jochen Beyer en_US
dc.date.accessioned 2012-10-12T03:35:55Z
dc.date.available 2012-10-12T03:35:55Z
dc.date.issued 2011 en_US
dc.identifier 2011000908 en_US
dc.identifier.citation Pham Annie Quynh Ngan, Fu Shanlin, and Dawson Michael 2011, 'Oxidation of MDMA in urine after exposure to bleach', , GI Printing & Graphics, Australia, , pp. 49-51. en_US
dc.identifier.issn en_US
dc.identifier.other E1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/19066
dc.description.abstract For the drug testing of MDMA (3,4-methylenedioxymethamphetamine or 'ecstasy') and other drugs of abuse, urine is generally the matrix of choice. However, the main issue concerned with urine drug testing is the lack of sample integrity due to acts of urine adulteration. A novel approach in the fight against urine adulteration is researched in this article, involving the use of LC-MS/MS (liquid chromatography-tandem mass spectrometry) to study and identify stable reaction products between the chemical reaction of MDMA and hypochlorite. Samples were analysed on an X Bridge C 18 column ( 150mm x 4.6mm, 3.51-Jm, Waters). Chromatographic separation was achieved at a tlow rate of 0.3ml/min using gradient elution involving 2mM ammonium formate solution in Milli-Q water and acetonitrile as the mobile phases. Kinetic experiments were performed whereby 11-JL of urinary reaction mixture was injected every 30min of reaction. One major reaction product, N-chloroMDMA, was formed and found to be unstable at room temperature (20?C), possibly reverting back into MDMA. It is suggested that bleach may possibly be able to oxidise a low dosage of MDMA to below cutoff concentration values and thus, conceal MDMA use. However, more research is required. en_US
dc.language en_US
dc.publisher GI Printing & Graphics en_US
dc.relation.isbasedon en_US
dc.title Oxidation of MDMA in urine after exposure to bleach en_US
dc.parent TIAFT Bulletin en_US
dc.journal.volume 41 en_US
dc.journal.number en_US
dc.publocation Australia en_US
dc.identifier.startpage 49 en_US
dc.identifier.endpage 51 en_US
dc.cauo.name SCI.Chemistry and Forensic Sciences en_US
dc.conference Verified OK en_US
dc.for 030499 en_US
dc.personcode 10310872 en_US
dc.personcode 103806 en_US
dc.personcode 910324 en_US
dc.percentage 100 en_US
dc.classification.name Medicinal and Biomolecular Chemistry not elsewhere classified en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom The international Association of Forensic Toxicologist (TIAFT) 2010 Meeting en_US
dc.date.activity 20100829 en_US
dc.location.activity Bonn, Germany en_US
dc.description.keywords mdma, ecstacy, drug masking, masking agents, urine testing en_US
dc.staffid en_US
dc.staffid 910324 en_US

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