Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

UTSePress Research/Manakin Repository

Search UTSePress Research


Advanced Search

Browse

My Account

Show simple item record

dc.contributor.author Cretney, Erika en_US
dc.contributor.author Takeda, Kazuyoshi en_US
dc.contributor.author Wiltrout, Robert en_US
dc.contributor.author Sedger, Lisa en_US
dc.contributor.author Kayagaki, N en_US
dc.contributor.author Yagita, Hideo en_US
dc.contributor.author Okumura, Ko en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-10-12T03:34:32Z
dc.date.available 2012-10-12T03:34:32Z
dc.date.issued 2001 en_US
dc.identifier 2011003802 en_US
dc.identifier.citation Cretney Erika et al. 2001, 'Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis', Rockefeller University Press, vol. 193, no. 6, pp. 661-670. en_US
dc.identifier.issn 0022-1007 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/18702
dc.description.abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed by in vitro activated natural killer (NK) cells, but the relevance of this observation to the biological function of NK cells has been unclear. Herein, we have demonstrated the in vivo induction of mouse TRAIL expression on various tissue NK cells and correlated NK cell activation with TRAIL-mediated antimetastatic function in vivo. Expression of TRAIL was only constitutive on a subset of liver NK cells, and innate NK cell control of Renca carcinoma hepatic metastases in the liver was partially TRAIL dependent. Administration of therapeutic doses of interleukin (IL)-12, a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells, upregulated TRAIL expression on liver, spleen, and lung NK cells, and IL-12 suppressed metastases in both liver and lung in a TRAIL-dependent fashion. By contrast, alpha -galactosylceramide (alpha -GalCer), a powerful inducer of NKT cell IFN-gamma and IL-4 secretion, suppressed both liver and lung metastases but only stimulated NK cell TRAIL-mediated function in the liver. TRAIL. expression was not detected on NK cells from IFN-gamma -deficient mice and TRAIL-mediated antimetastatic effects of IL-12 and a-GalCer were strictly IFN-gamma dependent. These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma -mediated antimetastatic effects of IL-12 and alpha -GalCer. en_US
dc.language en_US
dc.publisher Rockefeller University Press en_US
dc.relation.isbasedon http://dx.doi.org/10.1084/jem.193.6.661 en_US
dc.title Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis en_US
dc.parent Journal Of Experimental Medicine en_US
dc.journal.volume 193 en_US
dc.journal.number 6 en_US
dc.publocation USA en_US
dc.identifier.startpage 661 en_US
dc.identifier.endpage 670 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 110000 en_US
dc.personcode 0000076400 en_US
dc.personcode 0000076401 en_US
dc.personcode 0000076402 en_US
dc.personcode 102397 en_US
dc.personcode 0000062235 en_US
dc.personcode 0000076403 en_US
dc.personcode 0000076404 en_US
dc.percentage 100 en_US
dc.classification.name Medical And Health Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords HUMAN T-CELLS; NKT CELLS; ALPHA-GALACTOSYLCERAMIDE; IN-VIVO; MEDIATED CYTOTOXICITY; RECEPTOR EXPRESSION; DENDRITIC CELLS; CUTTING EDGE; TUMORICIDAL ACTIVITY; IMMUNE-RESPONSES en_US
dc.staffid en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record