The use of non-invasive ventilation for the relief of dyspnoea in exacerbations of chronic obstructive pulmonary disease; a systematic review

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dc.contributor.author Smith, Tracy en_US
dc.contributor.author Davidson, Patricia en_US
dc.contributor.author Lam, Lawrence en_US
dc.contributor.author Jenkins, Christine en_US
dc.contributor.author Ingham, Jane en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-10-12T03:34:27Z
dc.date.available 2012-10-12T03:34:27Z
dc.date.issued 2012 en_US
dc.identifier 2011001089 en_US
dc.identifier.citation Smith Tracy et al. 2012, 'The use of non-invasive ventilation for the relief of dyspnoea in exacerbations of chronic obstructive pulmonary disease; a systematic review', Blackwell Publishing Ltd, vol. 17, no. 2, pp. 300-307. en_US
dc.identifier.issn 1323-7799 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/18642
dc.description.abstract Background and objective: Non-invasive ventilation (NIV) improves outcomes in patients with acute exacerbations of COPD (AECOPD); however, the efficacy in relieving dyspnoea is uncertain. The objective of this systematic review was to identify, synthesize and interpret the data regarding the relief of dyspnoea afforded by NIV in patients admitted with acute respiratory failure occurring during AECOPD. Methods: Randomized controlled trials (RCTs) comparing usual medical care (UMC) to UMC plus NIV and reporting dyspnoea as a patient-reported outcome were identified by searching relevant databases and manual searching. The full text of potentially relevant articles was retrieved. Data describing the impact of NIV on dyspnoea was extracted. Results: Four RCTs met the review criteria.One found NIV did not relieve dyspnoea. The other three RCTs reported NIV relieving dyspnoea. The degree of dyspnoea relief was clinically significant in two of these three studies. However, in all but one RCT, methodological or reporting limitations constrain the confidence that can be had in this conclusion. Conclusions: Limited data exist to determine if NIV relieves subjective dyspnoea in AECOPD. Due to limitations in these studies, it is not possible to definitively conclude if NIV relieves dyspnoea. Standardized reporting and analysis of patient reported outcomes will facilitate objective comparisons of interventions with respect to symptom relief. Future studies involving NIV should routinely incorporate patient reported outcomes in order to answer the important clinical question: 'Does NIV relieve dyspnoea?' en_US
dc.language en_US
dc.publisher Blackwell Publishing Ltd en_US
dc.relation.isbasedon http://dx.doi.org/10.1111/j.1440-1843.2011.02085.x en_US
dc.title The use of non-invasive ventilation for the relief of dyspnoea in exacerbations of chronic obstructive pulmonary disease; a systematic review en_US
dc.parent Respirology en_US
dc.journal.volume 17 en_US
dc.journal.number 2 en_US
dc.publocation UK en_US
dc.identifier.startpage 300 en_US
dc.identifier.endpage 307 en_US
dc.cauo.name FOH.Faculty of Health en_US
dc.conference Verified OK en_US
dc.for 110300 en_US
dc.personcode 0000073301 en_US
dc.personcode 110950 en_US
dc.personcode 0000073304 en_US
dc.personcode 0000030993 en_US
dc.personcode 0000073305 en_US
dc.percentage 50 en_US
dc.classification.name Clinical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords chronic obstructive pulmonary disease; dyspnoea; non-invasive positive pressure ventilation; respiratory insufficiency; systematic; review en_US


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