Early hypothalamic FTO overexpression in response to maternal obesity - potential contribution to postweaning hyperphagia

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dc.contributor.author Caruso, V en_US
dc.contributor.author Chen, Hui en_US
dc.contributor.author Morris, Michael en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-10-12T03:34:25Z
dc.date.available 2012-10-12T03:34:25Z
dc.date.issued 2011 en_US
dc.identifier 2011000496 en_US
dc.identifier.citation Caruso V, Chen Hui, and Morris Michael 2011, 'Early hypothalamic FTO overexpression in response to maternal obesity - potential contribution to postweaning hyperphagia', Public Library Science, vol. 6, no. 9, pp. e25261 en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/18606
dc.description.abstract Background: Intrauterine and postnatal overnutrition program hyperphagia, adiposity and glucose intolerance in offspring. Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene have been linked to increased risk of obesity. FTO is highly expressed in hypothalamic regions critical for energy balance and hyperphagic phenotypes were linked with FTO SNPs. As nutrition during fetal development can influence the expression of genes involved in metabolic function, we investigated the impact of maternal obesity on FTO. Methods: Female Sprague Dawley rats were exposed to chow or high fat diet (HFD) for 5 weeks before mating, throughout gestation and lactation. On postnatal day 1 (PND1), some litters were adjusted to 3 pups (vs. 12 control) to induce postnatal overnutrition. At PND20, rats were weaned onto chow or HFD for 15 weeks. FTO mRNA expression in the hypothalamus and liver, as well as hepatic markers of lipid metabolism were measured. Results: At weaning, hypothalamic FTO mRNA expression was increased significantly in offspring of obese mothers and FTO was correlated with both visceral and epididymal fat mass (P<0.05); body weight approached significance (P = 0.07). Hepatic FTO and Fatty Acid Synthase mRNA expression were decreased by maternal obesity. At 18 weeks, FTO mRNA expression did not differ between groups; however body weight was significantly correlated with hypothalamic FTO. Postnatal HFD feeding significantly reduced hepatic Carnitine Palmitoyltransferase-1a but did not affect the expression of other hepatic markers investigated. FTO was not affected by chronic HFD feeding. Significance: Maternal obesity significantly impacted FTO expression in both hypothalamus and liver at weaning. en_US
dc.language en_US
dc.publisher Public Library Science en_US
dc.relation.isbasedon http://dx.doi.org/10.1371/journal.pone.0025261 en_US
dc.title Early hypothalamic FTO overexpression in response to maternal obesity - potential contribution to postweaning hyperphagia en_US
dc.parent Plos One en_US
dc.journal.volume 6 en_US
dc.journal.number 9 en_US
dc.publocation San Francisco en_US
dc.identifier.startpage 1 en_US
dc.identifier.endpage en_US
dc.identifier.endpage 7 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 111100 en_US
dc.personcode 0000072715 en_US
dc.personcode 105405 en_US
dc.personcode 0000024071 en_US
dc.percentage 100 en_US
dc.classification.name Nutrition and Dietetics en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Gene-Expression Analysis; Body-Mass Index; Childhood Obesity; Mitochondrial Dysfunction; Appetite Regulators; Adult Obesity; Energy-Intake; Food-Intake; Children; Variants en_US

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