Prescheduling graphic displays for optimal cancer therapies to reveal possible tumour regression or stabilisation

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dc.contributor.author Thornton, Barry en_US
dc.contributor.author Langtry, Tim en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-10-12T03:33:56Z
dc.date.available 2012-10-12T03:33:56Z
dc.date.issued 1988 en_US
dc.identifier 2011001138 en_US
dc.identifier.citation Thornton Barry and Langtry Timothy 1988, 'Prescheduling graphic displays for optimal cancer therapies to reveal possible tumour regression or stabilisation', Springer Science + Business Media, vol. 12, no. 1, pp. 31-41. en_US
dc.identifier.issn 0148-5598 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/18345
dc.description.abstract The paper describes an adaptive control approach to the problem of the treatment of solid tumors. The evolution with time t of the state of a tumor is modelled by a two-compartment system, governed by two differential equations forming an autonomous system under therapy control u, dy1/dt = f1(y1,y2;u) dy2/dt = f2(y1,y2;u), where y1 and y2 are the number of proliferating and nonproliferating cells, respectively. The output is analyzed in the phase plane y1y2. The control problem is that of restricting the tumor state to a predetermined region of the plane by selecting a suitable change in therapy control u, e.g., modality and dosage, when the state solution intersects the boundary of this region and the ratio y1/y2 of proliferating to nonproliferating cells is displayed together with an elapsed time scale. Then, consequent selection of a suitable therapeutic sequence may be assisted by the use of a data base as part of an expert system. The process is repeated at each intersection of the prescribed boundary. Such sequences may lead to stabilization of the system through the appearance on a computer display screen of a stable equilibrium point or a limit cycle. en_US
dc.language en_US
dc.publisher Springer Science + Business Media en_US
dc.relation.isbasedon en_US
dc.title Prescheduling graphic displays for optimal cancer therapies to reveal possible tumour regression or stabilisation en_US
dc.parent Journal of Medical Systems en_US
dc.journal.volume 12 en_US
dc.journal.number 1 en_US
dc.publocation USA en_US
dc.identifier.startpage 31 en_US
dc.identifier.endpage 41 en_US
dc.cauo.name SCI.Mathematical Sciences en_US
dc.conference Verified OK en_US
dc.for 090300 en_US
dc.personcode 994994 en_US
dc.personcode 830105 en_US
dc.percentage 100 en_US
dc.classification.name Biomedical Engineering en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords cancer therapy; human; methodology; short survey; tumor regression; Cell Division; Cell Survival; Computer Graphics; Computer Simulation; Drug Administration Schedule; Human; Models, Biological; Neoplasms; Remission Induction; Support, Non-U.S. Gov't; Therapy, Computer-Assisted; Time Factors en_US
dc.staffid en_US
dc.staffid 830105 en_US


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