Myxoma T2 protein as a model for poxvirus TNF receptor homologs

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Show simple item record Mcfadden, Geoffrey en_US Schreiber, M en_US Sedger, Lisa en_US
dc.contributor.editor NA en_US 2012-10-12T03:33:29Z 2012-10-12T03:33:29Z 1997 en_US
dc.identifier 2008005753 en_US
dc.identifier.citation Mcfadden Geoffrey, Schreiber M, and Sedger Lisa 1997, 'Myxoma T2 protein as a model for poxvirus TNF receptor homologs', Elsevier Science, vol. 72, pp. 2-119. en_US
dc.identifier.issn 0165-5728 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract Many poxviruses encode a plethora of immunomodulatory proteins, including homologs of cellular cytokine receptors. These receptor mimics, also referred to as viroceptors, are believed to function by binding and sequestering host cytokines thus preventing their signaling cascade prior to receptor engagement. The M-T2 protein of myxoma virus is a TNF receptor homolog that has two distinct activities: the secreted dimeric M-T2 protein binds and inhibits TNF alpha while the intracellular version permits myxoma virus replication in infected T-lymphocytes by blocking the cellular apoptosis response to the virus infection. Studies with M-T2 mutants reveal that distinct protein domains mediate these two anti-immune properties of this protein. en_US
dc.language en_US
dc.publisher Elsevier Science en_US
dc.title Myxoma T2 protein as a model for poxvirus TNF receptor homologs en_US
dc.parent Journal of Neuroimmunology en_US
dc.journal.volume 72 en_US
dc.journal.number en_US
dc.publocation Netherlands en_US
dc.identifier.startpage 2 en_US
dc.identifier.endpage 119 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060506 en_US
dc.personcode 0000018491 en_US
dc.personcode 0000050827 en_US
dc.personcode 102397 en_US
dc.percentage 60 en_US Virology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom International TNF Congress en_US 19960508 en_US
dc.location.activity Rhodes, Greece en_US
dc.description.keywords tumor necrosis factor; viroceptor; virokine; myxomatosis; vaccinia; apoptosis en_US
dc.staffid 102397 en_US

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